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The identification of dogs defective in ATP-binding cassette transporter B1 (ABCB1, MDR1) activity has prompted questions regarding pharmacokinetics (PK), efficacy and toxicity of ABCB1 substrates in these dogs. Assessing the effectiveness of coding and non-coding regions in antisense ribosome inhibition of gene expression in Tetrahymena. To provide normalized data for the determination of conceptus dose specific to gestational stage and treated spinal level. Stability of adsorbed states and site-conversion kinetics: CO on Ni(100). The purpose of this study was to compare endocrinologic and pathologic findings in birds with polyostotic hyperostosis.

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From these findings, it seems that PB stabilizes the hepatocyte membranes and reduces the mitochondrial formation of active oxygen species and that the stabilized functions of membrane and the reduction of oxidative stress result in the prolonged survival of hepatocytes in primary culture. In two studies subjects were required to read Dutch sentences that in some cases contained a syntactic violation, in other cases a semantic violation. Depression moderates between physical activity and quality of life in low-income children.

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Abundance of CRHin signal was low, commensurate with a low resting pool of CRH heteronuclear RNA (hnRNA), representing CRH primary transcript. Snails turned and followed water born odors from oysters, when tested with the odors of sexually active males, sexually active females, and copulating pairs, we found sex-specific differences in responses. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment. This study lends further support for the presence of dopaminergic dysfunction in schizophrenia, and demonstrates the advantages and problems in the use of multidiagnostic psychopathological evaluation to categorize a disorder where there is major disagreement among diagnostic systems.

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The effect of hemosorption (HS) on cardiodepressor activity of plasma deproteinates (PD) and plasma level of medium-size molecular peptides (MSMP) has been studied, using microbiuret technique, in 14 patients with thermic burns (group I--moderate burns, group II--severe burns). We used these data to prioritize pairs of drugs expected to reverse the changes in gene expression observed in the kidneys of a mouse model of HIV-associated nephropathy (Tg26 mice). Grand averaged potentials in SVCI showed a significant increase of P3 latency. Segmentation of lungs with large tumors is a challenging and time-consuming task, especially for 4D CT data sets used in radiation therapy.

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In the remote postresuscitation period (up to 2 months), expressed disturbances were revealed of the background thermomaps and of thermal reactions of the cerebral hemispheres, evoked by the stress influence. These results clearly demonstrate the in vivo antioxidant effect of U-74500A, a 21-aminosteroid in attenuating renal ischemia-reperfusion injury.

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In the alpha-chains one heme- and two alpha 1/beta 1-contacts were exchanged whereas in the beta-chains one alpha 1/beta 1-, one alpha 1/beta 2-and one heme-contact are substituted. These findings may assist in optimizing infliximab therapy in patients with inflammatory bowel disease. Height and weight of girls were not affected significantly by chronic asthma. Population responses recorded in hilar neurons accurately encoded stimulus identity.

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Assess and compare the clinical efficacy and safety of cochlear implantation in deaf patients with inner ear malformation and in the ones with normal inner ear structure, so that to clarify whether it is effective to restore hearing for the deaf patients with inner ear malformation. Natural organic matter concentration and hydrochemistry influence aggregation kinetics of functionalized engineered nanoparticles. Sexual size dimorphism and intraspecifically perceivable plumage dichromatism represent reliable traits that differ between female and male whiteheads.

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A randomized, controlled trial of screening is necessary to answer the many remaining questions. It is also shown that the test surfaces used in traditional slant-perception experiments contain no information about this direction. Use of alpha-agonists for management of anaphylaxis occurring under anaesthesia: case studies and review. By using ELISA, competitive ELISA with natural egg antigen as competitor, and Western blotting, 13 phage clones with high affinity and specificity to 6B12 were obtained and amplified from 400 single clones. Thirty-six obese adults received a protein-sparing modified fast (PSMF) consisting of 1.5 g of meat protein per kilogram of ideal body weight and meeting vitamin, mineral, and fluid requirements.

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Manipulation of thromboxane synthesis by novel 26,27-dialkyl analogues of 1 alpha,25-dihydroxyvitamin D3 in human promyelocytic leukemia (HL-60) cells. To determine the bedside accuracy of direct patient pressure monitoring when used with new and clinically used disposable blood pressure (BP) transducers.

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Several women-, staff-, and clinic-level barriers were identified that could hinder the successful implementation in antenatal services. In contrast, a fabric-covered, fully supported, stent-graft such as the AneuRx is significantly less compliant than the aorta or the bare-metal stent. To compare the changes in iris volume with pupil dilation using anterior segment optical coherence tomography (AS-OCT) in eyes of subjects with different subtypes of primary angle closure.

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Effects of prostaglandin E1 on plasma cytokine levels during pneumonectomy In contrast, IFN-alpha encapsulated in liposomes produced 35 percent and 60 percent cytostasis after a 30-minute and four-hour exposure, respectively. Deficits in joint action explain why socially anxious individuals are less well liked. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein-4 (UCP4).

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Hence, we hypothesized that the administration of VEGF encapsulated in PLGA nanoparticles (PLGA-VEGF NP) would promote fast healing due to the sustained and combined effects of VEGF and lactate. Although thermosensitivity can be complemented by the addition of DnaK and DnaJ proteins, restoration of near wild-type replication levels requires supplementary quantities of purified DnaA protein.

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We report here the differential expression of B1R and B2R in human benign and malignant prostate specimens. Focal treatment of spasticity using botulinum toxin A in cerebral palsy cases of GMFCS level V: evaluation of adverse effects. Small-scale drivers: the importance of nutrient availability and snowmelt timing on performance of the alpine shrub Salix herbacea. The extraction of these extracts requires the use of organic solvents, which not only complicates the formulations but also makes it difficult to directly use the extracts for humans.

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The role of electron microscopy is emphasized, since the histologic aspect of the lesion is similar to that of a primary vaginal mesonephric adenocarcinoma. So far, only short-term results are available in the literature.

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88 patients were recruited to complete two DASH questionnaires on two occasions 1-2 weeks apart. A Mr approximately 42 KD band was detected in denatured and non-reducing protein sample of rat testis and sperm with anti-mouse sp56 monoclonal antibody by Western blot method. Routine biological tests are frequently ordered in self-poisoning patients, but their clinical relevance is poorly studied. Self-assembly of virus-like particles of rabbit hemorrhagic disease virus capsid protein expressed in Escherichia coli and their immunogenicity in rabbits. Furthermore, the design of cleavable linkers for protein enrichment has lately received much attention.

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Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: a double-blind study. Multiorgan failure and triple acid-base disturbances that might develop secondary to postperfusion lung syndrome are responsible for the poor prognosis and increased mortality rather than postperfusion lung syndrome itself. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. Validation of biologic markers for use in research on chronic fatigue syndrome.

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The labelling was very intense with the GluR2 and GluR3 oligoprobes while it remained moderate with the NMDAR-1 oligoprobe. Effect of propranolol on ricinoleic acid- and deoxycholic acid-induced changes of intestinal electrolyte movement and mucosal permeability. Therefore, the frequency and intensity have to be optimized for the minimization of energy requirement during waste water treatment with ultrasound.

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NO2-PC was more hydrophilic than un-PC and reduced adhesion of bacterial protein and carbohydrate. The TPA enhanced 32Pi-incorporation into phospholipid fraction in HeLa cells was inhibited, and the micronuclei in mouse bone marrow cells induced by cytoxan was also depressed.

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Understanding the transcriptional regulation of an important class of innate and adaptive immune system effector molecules, the cytokines, is increasingly important given the promise cytokine regulation holds for treating various autoimmune and inflammatory diseases. MsbA transports lipid A, its native substrate, across the inner membrane of Gram-negative bacteria. Language and memory profiles of adolescents with traumatic brain injury.

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This study reports our experience with fasciocutaneous reconstruction of circumferential pharyngoesophageal defects using an anterolateral thigh flap wrapped around a salivary bypass tube. Cultural adaptation and psychometric validation of the health-related quality of life questionnaire EORTC QLQ STO-22 for patients with gastric cancer in Peru Attitude towards euthanasia in relation to death anxiety among a sample of 343 nurses in India. Negative controls were obtained by applying antiserum which had been preabsorbed overnight with excess inhibin peptide in place of primary antiserum and also normal nonimmune sheep serum as a substitute for primary antiserum.

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Zebrafish exposed to NaF in laboratory condition showed hyperactivity and frequent surfacing activity, somersaulting and vertical swimming pattern as compared to the control group. Suppression of Egr-1 protein expression in okadaic acid-treated SCCKN cells stemmed from the suppression of the Egr-1 mRNA level, as determined by the RT-RCR method.

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The Architect iDigoxin CMIA assay would be relatively free from endogenous DLIS positive interferences. Three proteins of the subtilin gene cluster (SpaB, SpaC, and SpaT) which are probably involved in prepeptide modification and transport have been identified genetically (C. Hook screw fixation shows biomechanical advantages and is safe and effective for young patients with lumbar spondylolysis. Identification of Staphylococcus species in blood cultures by a rapid commercial DNA probe test. Uniformly offering patients total thyroidectomy seems to be an overly radical approach.

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Influence of the freezing-thawing-washing procedure on the cytomegalovirus DNA content of cellular blood products. The hepatorenal syndrome represents the result of extreme vasodilatation with an extreme decrease in effective blood volume that leads to maximal activation of vasoconstrictive systems, renal vasoconstriction, and renal failure. Pesticides in urban streams and early life stages of Pacific coho salmon. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell division during mitosis. Surveillance cultures to monitor quality of gastrointestinal endoscope reprocessing.

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However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. Consequently, current theories are unable to explain the existence of olfactory contrast enhancement. The present study compared heat pain threshold, obtained through a method that involves reaction time participation, with heat pain thresholds obtained bypassing reaction time. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects.

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To assess the feasibility, internal reliability, and validity, of an assessment tool, purpose-based information assessment (PIA), that we had developed to evaluate how effectively information provided to patients addresses their individual purposes for the information. These results indicate that the vascularly perfused intestinal preparation has wide applications in biochemical experimental fields.

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Cobalt-mediated radical coupling (CMRC): an unusual route to midchain-functionalized symmetrical macromolecules. Motion profiles were asymmetrical waveforms with amplitudes of 10, 15, and 20 mm and a 4-second cycle.

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The therapeutic tactics in thyreotoxic crisis and the preoperative and postoperative management of patients are discussed. The study reveals the human cost of critical illness and intensive care for patients and partners in the Danish welfare system. Cat-scratch disease during anti-tumor necrosis factor-alpha therapy: case report and review of the literature. The Authors have suggested the clinical application of this kind of prosthesis and the Authors have reported about two clinical cases that have had first a periodontal treatment then a Maryland Bridge prosthesis.

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Decoding Concrete and Abstract Action Representations During Explicit and Implicit Conceptual Processing. Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: a possible window of opportunity effect. The study found that early sexual debut, non-use of contraception during first sexual intercourse, living in a very poor household, having suffered from sexual abuse during childhood-adolescence, and family disruption (living extended periods of life without both parents) were associated with adolescent pregnancy in Orellana. Pharmacokinetics of Compound D, the Major Bioactive Component of Zingiber cassumunar, in Rats. These data support the concept that, within cortical regions, changes in gene expression are associated with alcoholism-related pathology.

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This method validated a previously reported radioimmunoassay for imipramine and desipramine. K32 cells, but not U32 cells, loaded with anti-CD3 alone also stimulated CD4 T-cell growth and IL-2 secretion, indicating the expression of additional costimulatory molecules on K32 cells. Cardiac energy balance is an important factor in evaluating cardiac function. Lesions up to 8 cm in length of the femoropopliteal arteries can be treated successfully in most cases with the new atherectomy catheter. The autoregressive parameter is allowed to change over time according to a Bayesian changepoint model with unknown number of changepoints.

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In this prospective study a standardized protocol for the diagnosis and management of VA-injury following blunt cervical spine trauma with subluxation or fractures affecting the transverse foramen was evaluated. Observational studies and randomized trials to test this hypothesis could ultimately lead to the development of novel treatments for atopic diseases, such as allergic asthma, hay fever, and eczema. It was shown that HTLV-I enhances HIV-1 expression, but whether HIV-1 activates HTLV-I remains to be demonstrated. NTP Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CAS No. Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

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Sequencing of part of the 1D gene of foot-and-mouth disease virus was used to determine the relationships between SAT-2 viruses isolated from outbreaks which occurred in cattle in Zimbabwe and Namibia and in impala in South Africa between 1979 and 1989. These results suggest that (1) mechanisms other than differential induction and repair of strand breaks are responsible for the increased radiation sensitivity in LZ, and (2) the lack of Adriamycin-induced DNA damage in LZ is at least partially responsible for the increased cell survival after treatment.

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Hemi-mandibles were radiographed, imaged by computed tomographic reconstruction, and reformatted. Activation of Jurkat cells with the combination of PMA and PHA leads to increased expression of PLC-alpha message and decreased expression of PLC-gamma message after 4 h of stimulation.

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The results of our study suggest that careful observation of seizure semiology may be useful for the differentiation of ictal onset areas. Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy?

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We present an exceptional case of testicular seminoma metastasis in intraluminal ureter, manifested by obstruction of the lumen with pyonephrosis. Bipolar disorder, obesity, and pharmacotherapy-associated weight gain. Methods of isolation and cryopreservation of stem cells from cord blood.

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However, in case of murder or homicide this might become necessary to answer forensic questions such as the ability to move or other actions of the victim. The interpretation of the data was focused more on the realtime response anomalies on random cases than on ensemble statistical data evaluation. A DNA-based carrier test was developed and currently is used by TFT breeders to prevent this disorder. The absence of a conceptually sound and well-validated ADHD-specific quality-of-life measure has been an obstacle to understanding this impact.

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However, few studies have assessed the effect of topical corticosteroids on daytime fatigue and sleep. Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone. Col2a1 expression and glycosaminoglycan (GAG) content were measured in ATDC5 cells treated with GRIP1 small interfering RNA (siRNA). Hypothalamic tissues were collected for gene expression analysis at the end of the 3 h tail suspension period.