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We also analyzed the maximum firing rate (FRmax) and the latency of the responses as a function of VOT and gap duration and found a significant reduction in the FRmax to the trailing noise burst for gap durations above 50 ms. Guidelines for clinical trials of new therapeutic agents in multiple sclerosis: relations between study investigators, advisors, and sponsors. Steroid hormone biosynthesis is catalyzed by the action of a series of cytochrome P450 enzymes as well as reductases.

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The blocking effects of SB 242084 likely involved 5-HT(2C) receptors because the drug did not demonstrate 5-HT(2A) receptor occupancy in vivo or ex vivo. Our study aimed at identifying common differentially expressed genes during late oogenesis in both species. Relationship of mitral annular remodeling to severity of chronic mitral regurgitation.

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We evaluated in vitro the litholytic potency of taurine-amidated bile salts against human cholesterol gallstones. In cultured cells, the p90MDM2 protein blocks the transcriptional activation domain of p53 and also stimulates the degradation of p53. Ectopic expression of neuron-specific splicing regulatory proteins of the Nova family was observed in some cell lines and tumor samples, correlating with expression of a neuron-specific mRNA isoform of JNK2 kinase. Tumor cell adhesion to extracellular matrix (ECM) components is mediated via integrin subunits, and plays a major role in the invasion and metastasis of tumor cells. This lesion seemed to arise from an inflammatory process obstructing pneumatized cells.

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Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): histological observations. Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells. LDPI showed no difference in blood flow between the reconstructed ear and the normal ear, neither before nor after indirect heating. Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET. All patients described unrefreshing sleep and showed a prominent alpha electroencephalographic nonrapid eye movement (7.5-11.0 Hz) sleep anomaly (p less than or equal to 0.001), but had no physiologic daytime sleepiness.

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Using an experimental method in which the cognitive sets of raters were manipulated as dimensional versus categorical, it is demonstrated that pseudotaxonicity can be created readily with rating scale measures. Mortality peaks reflect epidemics of malaria and diarrhoeal disease. Magnetic resonance imaging found thromboembolism in the inferior vena cava and a large heterogeneous mass in the pelvis. One often identified effect of opioid administration is that of the development of tolerance to the analgesic effect.

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Thiyl radicals react with (alpha)C-H bonds with rate constants between 1.7 x 10(3) M(-1) s(-1) (N-acetylproline amide) and 4 x 10(5) M(-1) s(-1) (sarcosine anhydride). One-Step Nucleic acid Amplification (OSNA) is a molecular biological assay of cytokeratin-19 (a breast epithelial marker) mRNA. The process might occur with or without participation of reactive oxygen species.

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Compositional variability in essential oil from different parts of Alpinia speciosa from India. Cachexia as a major public health problem: frequent, costly, and deadly. Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes. This structure is supported by not only main shocks but also small shocks, and may have its origin in the combined effect of vertex fitness and deactivation by stress release at faults.

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Their renal clearance is higher and the maternal intravascular volume is expanded. A comparative study of the central nervous system effects of betaxolol vs timolol. In contrast, we found that optimal concentrations of rSpA as well as crude and HPLC purified staphylococcal SpA were equally effective in inhibiting the growth of established Meth A fibrosarcomas demonstrating that SpA is responsible for antitumor activity without any apparent role for enterotoxins. Analysis of smoking policies at state-operated or state-supported psychiatric inpatient hospitals found significant movement in adopting nonsmoking policies and some increase in active treatment, notably wellness counseling.

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There was no evidence that an anthelmintic treatment combined with a movement of sheep to pastures of low infectivity selected more rapidly for resistance than where the same number of treatments were given to set-stocked sheep. The contribution of endogenous corticosterone to the incidence of cleft palate in mice. Residual stress varied significantly among the contemporary dental composites indicated for restoring posterior teeth. For full activation and DNA binding, the homodimeric protein requires the binding of two cyclic AMP (cAMP) molecules in an anti-cooperative manner, the source of which appears to be largely of entropic nature according to previous experimental studies.

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Changes in graduate medical education associated with full implementation of the Balanced Budget Act of 1997 have required medical schools to review and revise their curricula. Adaptive responses of rat tissue isoferritins to iron administration. Incidence of Dysphagia and Serial Videofluoroscopic Swallow Study Findings After Anterior Cervical Discectomy and Fusion: A Prospective Study. Sufficient nutritional repletion coupled with appropriate supportive treatment modalities may be effective in reducing complications associated with ALD---particularly infection. Effect of long-range potential fluctuations on scaling in the integer quantum Hall effect.

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Early identification of treatment non-response utilizing the Patient Health Questionnaire (PHQ-9). Of 10 partial hydatidiform moles, 8 were triploid and 2 were diploid. Hepatic expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) and genes involved in fatty acid activation, peroxisomal and mitochondrial beta-oxidation, and production of ketone bodies was decreased. The toxic potency values are assessed to determine if the smoke from a material or product is unusually or extremely toxic and can then be used in computations of fire hazard. An unprecedented fatal case of pseudomembranous colitis (PMC) is described, associated with the use of topical antibiotics (neomycin and erythromycin base) during whole gut irrigation.

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Subjective evaluations of confidence in these skills did not improve significantly compared to controls, corroborating the need for using objective outcome measures when assessing simulation-based training. Most frugivores engage in some form of destination-based dispersal, in that they move seeds towards specific destinations, resulting in clumped distributions of seeds away from the source tree. The phases have been completed with good results: reliability (ICC) of prevalent symptoms was above 0.75, good feasibility and good compliance. The authors present their experience with the use of continuous monitoring of cerebral tissue pressure (CTP) in a neurosurgical intensive care unit.

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A review of social housing regeneration in the London Borough of Brent. Nitrate derivatives have in vivo and in vitro platelet anti-aggregant properties in addition to their vasodilatory effects.

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Eleven patients with TN and MS who were treated by the senior author (N.B.) at the University of California, San Francisco were included in this study. In a 24-hour-old newborn baby with bleeding in the subarachnoid space it was found macrophage with hemosiderin. A web-based application was developed to remotely view slide specimens and control all functions of a research-level light microscopy workstation, called AccessScope. Our analysis revealed that social relations are beneficial for health behaviors such as chronic illness self-management and decreased suicidal tendency. The purpose of this study was to present a pathophysiological consideration of this assumption, together with two cases which support it.

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We introduced the four missense mutations linked to FHM into human alpha1A-2 subunits and investigated their functional consequences after expression in human embryonic kidney 293 cells. At supine rest as well as during sitting and standing, hypertensive subjects had plasma norepinephrine concentrations similar to those in normotensive control subjects, but plasma dihydroxyphenylglycol concentrations were higher than those in normotensive control subjects. We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases.

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Conformationally controlled oligocholate membrane transporters: learning through water play. Physicians had to perform emergency manual removal of the placenta under general anesthesia.

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Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. It consisted of intersecting fascicles of spindle cells, which lacked mitoses and significant atypia, and were immunopositive for smooth muscle markers. Mechanisms of autoantibody diversification to SLE-related autoantigens.

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Here, we look at targeting sequences of the microsporidian mitosomal import system and show that mitosomes do in some cases still use N-terminal and internal targeting sequences that are recognizable by import systems of mitochondria in yeast. Comparison of the Leiter International Performance Scale-Revised and the Stanford-Binet Intelligence Scales, 5th Edition, in children with autism spectrum disorders. To highlight the frequency and features of the complication of conductive hearing loss following retrolabyrinthine surgery.

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The spatial and temporal organization of DNA replication was investigated in living cells with a green fluorescent protein fusion to the DNA polymerase clamp PCNA. Specific gene-targeted mice have unveiled critical, non-overlapping functions for SOCS1 and SOCS3 in lymphocyte development and homeostasis, and in the regulation of macrophage and dendritic cell functions. Allergic reactions to plant and animal derived food allergens can have serious consequences for sufferers and their families. The fluorescence spectrum of a distinct isometric and conformational intermediate formed on the 10(-11) s time scale during the bacteriorhodopsin (BR) photocycle is observed at room temperature using a two laser, pump-probe technique with picosecond time resolution. 99Tc(m)-MDP three-phase bone scintigraphy and 99Tc(m)-MIBI dynamic and quiet states scintigraphy were obtained from 39 patients with proved malignant diseases or suspected bone metastases after bolus injected intravenously radiopharmaceuticals, respectively.

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Polyglactin implantation increases the local inflammatory response and should not be used for nerve anastomoses. Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse: an animal model useful for studies on cognitive enhancers.

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This emphasizes the need for standardized methods of measurements of QRS end-J point-ST segment and for detailed definitions. The melanocortin 1 receptor (MC1R), a G(S)-protein-coupled receptor (GPCR), is a key regulator of proliferation and differentiation of epidermal melanocytes, and a determinant of human skin phototype and cancer risk.

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The patient attended the clinic, and accompanied by a responsible family member. The change in climate will put further pressure on the sensitive environment of high mountains. The identified known proteins were classified into three ontologies of cellular component, molecular function, and biological process. Questioning centered on the impact of the primary care course both in relationship to medicine as a whole and to general practice.

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Especially, the separation step-dialysis, or ultrafiltration-implies important technical and theoretical uncertainties and interferences as to the methods.Furthermore, a short review of methods based on isotope dilution/mass spectrometry (ID/MS) to quantify thyroxine is provided. Cyclooxygenase-2 (COX-2) is involved in inhibition of apoptosis, potentiation of cell growth, and angiogenesis and as such is a target for drug development.

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