Spamilan is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, Spamilan is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, Spamilan does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, Spamilan been termed 'anxioselective'. First synthesized in 1968 then patented in 1975, it is commonly marketed under the brand name Spamilan. Spamilan was first approved in 1986 by the FDA and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate. The potential use of Spamilan in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has also been investigated.
Other names for this medication:
Buspirone,
Buspar,
Ansial,
Ansitec,
Ansiten,
Anxinil,
Anxiron,
Bespar,
Busansil,
Busirone,
Buspin,
Buspiron,
Buspirona,
Ledion,
Narol,
Neurosine,
Paxon,
Sorbon,
Spamilan,
Spitomin,
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Tamsin,
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Extracorporeal photochemotherapy (ECPCT) is a new form of chemoimmunotherapy which involves the ex vivo exposure of malignant peripheral blood cells to 8-methoxypsoralen (8-MOP) and ultraviolet A (UVA) radiation followed by reinfusion of the treated cells. Plasma prolactin (PRL) levels increased after pituitary grafting at all time points examined. Here, we report a case of anastomotic perforation 5 years after subtotal gastrectomy due to perforated duodenal prosteride review times ulcer and gastric NETs.
Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia - an individual patient data meta-analysis involving 5,659 children. To investigate the preferences of children with cancer, their parents, and survivors of childhood cancer regarding medical communication with child patients and variables associated with these preferences. The functional network structure of each subject is clarithromycin pregnancy warnings encoded in a diffusion map, where functional relationships are decoupled from spatial position. Parametric driving of dark solitons in atomic Bose-Einstein condensates.
In 151 reported cases, including present cases, 17.4 percent have moderate to severe or at least subjective deafness, 45.0 percent have deafness only at high frequency, 6 percent have deafness for which the severity was not described, 13.4 percent have normal hearing, and in 18.1 percent the status of hearing was not mentioned. Promoter mutations that affected LCP-1 binding reduced early mRNA transcription during the early phase of the lytic cycle. Furthermore, the IGF-I-mediated inhibition of PARP could be demonstrated as a result of protein phosphorylation since phosphorylation of PARP decreased its activity in vitro and IGF-I treatment herclov 500 mg naproxen of endothelial cells induced PARP phosphorylation.
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