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The stability of ifosfamide in aqueous solution and its suitability for continuous 7-day infusion by ambulatory pump. Perturbation of Tub4p function, either by conditional mutation or by depletion of the protein, results in spindle as well as spindle pole body defects, but does not eliminate the ability of microtubules to regrow from, or remain attached to, the spindle pole body. Thus, HESR1 plays a key role in the finely tuned network of molecules involved in the regulation of retinal vascular homeostasis. The integration of nanoparticles, which exhibit unique electronic, photonic, and catalytic properties, with biomaterials, which display unique recognition, catalytic, and inhibition properties, yields novel hybrid nanobiomaterials of synergetic properties and functions. All items were appropriate and did not cause embarrassment to the participants.

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Georgia hospitals prepare for April 14 HIPAA implementation deadline. Six domains of collaborative research capacity were identified and used to develop a model. A combination of recently developed methods, such as 3-dimensional facial morphometry and Fourier analysis, should allow a more comprehensive knowledge of growth and development of the craniofacial structures, including the facial profile.

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Is FDG-PET scan in patients with early stage Hodgkin lymphoma of any value in the implementation of the involved-node radiotherapy concept and dose painting? There is now much evidence to suggest that UVA acts to promote tumors that have been initiated by UVB. To our knowledge this is the first report published on this subject in the scientific literature. Histopathological examination of the brain and eyes of three of the families showed typical primitive neuroectodermal tumors.

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The IgG subclasses of anti-48 kDa La(SSB) and anti-52 and 60 kDa Ro(SSA) do not account for the susceptibility of one fetus versus another for the development of CHB. In in vivo experiments, aortic tissue specimens including the flow dividers of the branching of the left subclavian artery and the aortic intercostal ostium were obtained and their endothelial cell shapes were observed using the scanning electron microscope. Resonance effects in the carrier-tunneling dynamics in asymmetric coupled quantum wells.

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The data provide direct evidence for the unprecedented finding that the entire length of a kDNA minicircle is transcribed in T. This study investigates to what extent the amount of variation in a visual scene causes speakers to mention the attribute color in their definite target descriptions, focusing on scenes in which this attribute is not needed for identification of the target.

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In addition the effect on behaviour of neutralization of centrally available alpha-MSH by intracerebroventricular administration of antisera to alpha-MSH was investigated. The quasi-type-II feature of the colloidal dots is confirmed with time-resolved photoluminescence (PL) measurements. We present in this case report the return to flying duty of a pilot with vocal cord paralysis secondary to removal of a thymoma. Current status, problems and countermeasures for properties theory of Chinese medicinal herbs Our urethroplasty technique can be used to correct various types of anterior urethral stricture or hypospadias associated with insufficient penile or preputial skin.

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Questions have been raised about some of the studies now in the literature regarding the use of the hospital as the unit of analysis and the cross-sectional design of the studies. To assess the degree of improvement, patients and their partners were asked to grade any improvement in percentage terms. Insulin resistance, measured by the euglycemic/hyperinsulinemic glucose clamp method, improved and blood glucose, diastolic blood pressure and serum cholesterol decreased with testosterone treatment.

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In order to collect ethnobotanical information about antimalarial plants which is essential for the further evaluation of the efficacy of plants an antimalarial remedies, we investigated the management of malaria with traditional herbal remedies, including the use, preparation and administration, by traditional healers in Tanzania. Overall, the cultural model of Latino intercultural competence includes a set of skills that integrates traditional cultural values along with attributes of self-efficacy. The authors present a brief history of high-standard records of the electric activity of the human heart.

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It has been demonstrated that a simple two-compartment kinetic model may account for the changes in plasma concentration of pancuronium after i.v. However, in the aftermath of this immense increase in data, functional studies of both protein-coding and non-coding transcripts are lagging behind. In our present series, the patients with obturator hernia were slender females at an advanced age.

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Rates for 1991-2001 may differ from those published previously based on the 1990 U.S. The mutation prevents this interaction suggesting that the mutant phenotype is caused by the accumulation of IAA1/AXR5. The alginate-producing derivative grew significantly slower in vitro growth but showed increased epiphytic fitness and better symptom development in planta.

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The abundance of disease-specific mutations and their location at multiple sites across the genome have limited molecular genetic diagnosis to kindred of known patients, and confirm the necessity for de novo screening by well-proven clinical and biochemical means. Such manipulation tends to disrupt fiber assembly since the knob region contains a stabilization element for fiber trimerization.

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The toxin, in a dose-dependent manner, decreased the amplitude of the stimulated peak tension of isolated fibers. An aqueous solution of non-ionic surfactants becomes suddenly turbid when heated to a critical temperature, known as the cloud point, and concomitantly expands the volume.

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Various organizations of the complex repeats in vole sex chromosome heterochromatin. Chickens were given various fowlpox vaccines on food pellets--a commercial vaccine (strain M), and the same strain after a single passage on chorio-allantoic membrane or in chicken embryo fibroblasts. Our results establish mutations in PRODH2 as a cause of human hydroxyprolinemia via impaired dehydrogenation of hydroxyproline to delta1-pyroline-3-hydroxy-5-carboxylic acid, and we suggest PRODH2 be renamed HYPDH. In some patients, treatment is not effective and suppression of viral replication is not achieved.

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No worms were found to have perforated the entire intestinal wall as was described from human patients in China. Trauma team activation criteria as predictors of patient disposition from the emergency department.

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Psychotropic drugs increase the risk of falls, but they are still frequently prescribed to treat behavioral symptoms associated with dementia in the nursing home. It consisted of a unique combination of adenoid cystic, squamous and small cell neuroendocrine structures. Experiences with minimal intermittent heparinization in chronic dialysis patients

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A study on adaptive IMRT treatment planning using kV cone-beam CT. In the perivasculature, NPY-immunoreactive fibers were more numerous than other immunoreactive fibers. The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Medial collateral ligament strain with partial posteromedial olecranon resection. During the development, molecules of membrane fatty acids become more and more complex, and the ratio of polyenic fatty acids/saturated fatty acids in the brain rises, while the concentration of monoenic fatty acids remained relatively stable.

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Activity-induced internalization and rapid degradation of sodium channels in cultured fetal neurons. Increasing resistance of pathogenic bacteria to antibiotics is a severe problem in health care and has intensified the search for novel drugs.

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In a 12-week, multicenter, double-blind, randomized, active- and placebo-controlled dose-finding study, patients were randomized to one of four ipragliflozin treatment groups (12.5, 50, 150, and 300 mg once daily), placebo, or active control (metformin). Sonographic findings in a patient with cystic hypersecretory duct carcinoma of the breast. The Authors suggest a more aggressive approach possibly inclusive of cardiac biopsy when doubtful cases of athlete heart require permission for competitive sports.

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Access to dental care for children in the United States: a survey of general practitioners. To address this gap, a field evaluation was carried out to determine the acceptability and durability of Interceptor((R)) LLINs. In phase 2, the significant epistatic interactions observed in phase 1 were tested in an independent population gathering 1,755 unrelated European adults. Apparently, X-irradiation did not affect these kinase activities at the 1- and 2-cell stages in either mouse strains regardless of their difference in radiation sensitivity. There is an average of 2.0-6.6 alleles per locus and observed individual heterozygosity of 0.33-0.50 in most herds.

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The distal epididymis and ampulla of the epididymis possessed many fingerlike projections and transverse septa, respectively. We evaluated the methods used and quality of reporting split-mouth studies. Synergistic interaction in vitro with use of three antibiotics simultaneously against Pseudomonas maltophilia.

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The potential of this agent was consequently explored in a life-supporting pig-to-primate renal model using the cynomolgus monkey as the recipient species. These data support the hypothesis that SOD protects the intracellular V. Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues. One of the MFH cases died 6 months after diagnosis, and the other MFH case and the OS case are alive without disease 3 years and one and a half years after surgery, respectively. Depletion of NBS1, with or without depletion of other members of the complex, resulted in inhibition of ALT-mediated telomere maintenance, as evidenced by decreased numbers of ALT-associated promyelocytic leukemia bodies and decreased telomere length.

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Extinction rates should not be estimated from molecular phylogenies. CBT resulted in improvement in symptoms of anxiety and depression, with effect sizes of 1.1 and 0.9 at post-treatment, respectively. The management of patients with STDs is an important element in the fight against AIDS. The aim of this study was to investigate whether human primary trabecular meshwork (HTM) cells secrete MMP-3 after stimulation by SLT. Also, subject age was significantly associated with the number of unstimulated cells and T cell proliferation to positive activators.

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VZV neurotropism was not disrupted when DRG xenografts were infected with rOka mutants lacking gI promoter elements that bind cellular transactivators, specificity factor 1 (Sp1) and upstream stimulatory factor (USF). While monitoring the intracranial pressure, the baby was treated with temporary external subdural drainage, followed by a permanent subdural peritoneal shunt. On each side of the candidate gene loci, one to two highly polymorphic microsatellite markers were genotyped in 474 subjects recruited from 106 hypertension nuclear families in Shanghai.

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Here we have used gene arrays to identify several other targets for Brn-3b in human breast cancer cells, including cyclin-dependent kinase 4 (CDK4). Inhibition of this 15-lipoxygenase blocked EGF-dependent hydroxyoctadecadienoic acid formation and mitogenesis but did not affect EGF-stimulated c-jun or jun-B mRNA accumulation.

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Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. caricae, and many of the records of this fungus are considered to be doubtful or incorrect, either omitting a description of the fungus or including a description or illustration of an euodium conidiophore morphology. The introduction of endovascular techniques opened new possibilities of treatment.

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A level of 20 per cent moisture content was reached after different time intervals in different strains of merino sheep, which may explain one of the differences in strain susceptibility to fleece rot Hamsters and mice were infected with this new SFVmac isolate to evaluate whether hamsters are also susceptible to infection.

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Convergent and discriminant validity of the CIQ were demonstrated by correlation patterns with MPAI scales in the expected direction. Early detection of infection is critical to rapidly starting effective treatment.

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We describe the case of a 64-year-old woman with a previous diagnosis of celiac sprue and no clinical or histological response to gluten withdrawal. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community.

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The koalas were anesthetized using alfaxalone intramuscularly and isoflurane via face mask, then maintained on isoflurane after endotracheal intubation. Osteochondritis dissecans and other lesions of the femoral condyles.

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The first part examined research on pain in people with dementia and the challenges nurses face with pain assessments. Effects of profound sensorineural loss on gerbilline auditory encephalopathy. While extreme nonadherence is readily apparent, it is rare compared to lesser degrees of nonadherence, which are difficult to predict. The HLA antigen distribution in 19 of the 21 children was compared with that of 1967 healthy adults. If we rise to the occasion and face these challenges, then we will be better equipped to meet the evolving needs of clinicians, researchers, and most importantly patients.

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VEGF and bFGF concentrations were determined using a quantitative sandwich enzyme immunoassay technique. DNA sequencing identified the mutations as Gly460Asp, Arg544Gly, Glu548Gly, Thr571Ile, His575Tyr and His579Tyr. Detection of antibodies to melanocytes in vitiligo by western immunoblotting.

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Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. We hypothesize that down-regulation of these HLH transcription factors is required for initiation of regenerative response to axonal injury. Modulation of the electrophysiological correlates of retrieval cue processing by the specificity of task demands. Here we show by immunogold electron microscopy that GAD65 is localized to the membrane of small vesicles which are identical in size to small synaptic-like microvesicles in pancreatic beta-cells.