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Novacan (Fluconazole)

Novacan is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zolax, Zoldicam, Zolen, Zoloder, Zucon,

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The prognostic role of the JAK2V617F mutation and of its allelic burden has been the objective of intensive research using a variety of cellular and animal models as well as in large series of patients. The second peak of leptin may be the signal of the end of puberty. Addition of the electron donor acetate was used to stimulate a redox profile in sediment columns, from oxic to Fe(III)-reducing conditions. These groups are likely to have diverged in the Pleistocene, corresponding to geological changes and the interglacial-glacial climate oscillations that occurred at the eastern margin of the Qinghai-Tibetan Plateau. The three dimension structure of collagen were changed but not seriously destroyed and the model of photooxidation reaction was validated.

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Laparoscopic sacral colpopexy (LSC) for pelvic prolapse is a complex procedure, characterized by long operative times and, when combined with supracervical hysterectomy, by a high risk of spreading of unsuspected cancerous tissue. TB clinics with highly integrated pre-ART services appear to be efficient sites for introducing ART given that co-infected patients are already engaged in care, and may potentially facilitate earlier access to treatment and minimize loss to follow-up. These results indicate that growth of the human squamous cell carcinoma MH-85 is dependent on the EGFR pathway and that subsequent development of hypercalcemia and cachexia is dependent on tumor growth.

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Genes, related to the biosynthesis of bacteriocins and riboflavin, were identified. Additional studies are needed to determine whether children living in foster care achieve oral health, and the extent of their unmet dental need. Conformational identity of human fibrinogen and monomeric fibrin.

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Multiple Imputation to Correct for Nonresponse Bias: Application in Non-communicable Disease Risk Factors Survey. An instrument for evaluating th medical interview in general practice: VR-MICS/D (Verona-Medical Interview Classification System/Doctor) Effects of polyethylene glycol conjugated superoxide dismutase on coxsackievirus B3 myocarditis in mice. Electronic versus paper-based nursing documentation systems: the caregivers weigh in. Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma.

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This review summarizes current knowledge on the role of CD44 in metastasis, as well as the challenges on understanding how this process operates. Since the availability of electronic axiographic tracers, the movement of the condyles can be resolved with high resolution both in space and in time. Efficient cyclic system to yield ectoine using Brevibacterium sp.

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The transfer of the HIV-1PR marker gene could be detected in vivo after intratumoral delivery of the human simplex virus-amplicon vector. Here we approach this problem from the perspective of dynamical systems theory.

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The utilization of high-frequency oscillatory ventilation has dramatically increased in neonatal and pediatric intensive care units. A study of the expression of these genes might allow us to identify the regulatory gene which determines differentiation. Recognition of the injury and identification of the responsible animal is crucial for quick and successful management. Significant downward advection in this bank filtration setting depletes the Mn and Fe oxides in the sediments and enhances the transport of dissolved Fe and Mn into the infiltrating water. To determine the extent of the problem a course evaluation study that measured the knowledge loss of medical students on selected first year courses was conducted.

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Solid-phase microextraction for the analysis of short-chain chlorinated paraffins in water samples. It also possesses a higher concentration of the receptor in its mucosa compared to the muscle layer.

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The current instrument can support the design of educational interventions and training programmes and reduce inconsistencies in the information that patients receive. Among these, protein-protein interactions (and in particular interactions with other receptors leading to heteromerization) has been shown to have an important role in modulating GPCR function. The ABR seems to have less predictive value when advanced skin changes are present, and in such cases the extent of ischemic necrosis is probably the major determinant of outcome. In the diabetic patients, aspirin therapy was followed by a decreased glucose response to I.V.

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MDCK-ras-e cell lines were cloned in vitro from MDCK-ras cell cultures. Of these 400, only the 332 women who did not receive axillary radiotherapy were included in the analysis. The immunopathologic effects induced by two attenuated chicken anemia virus (CAV) isolates, known as cloned isolate 34 (CI 34) and cloned revertant isolate 18 (CRI 18), that were derived from highly passaged pools of Cux-1 CAV isolate, were compared with those induced by a pathogenic, molecularly cloned, low-passage Cux-1 isolate (CI Cux). This report describes laparoscopic superior mesenteric artery first approach, in which the superior mesenteric artery is dissected in the early phase of resection. Toxic effects of polychlorinated biphenyl bioaccumulation in sea urchins exposed to contaminated sediments.

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