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Novacan (Fluconazole)
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Fluconazole

Novacan is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zolax, Zoldicam, Zolen, Zoloder, Zucon,

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The prognostic role of the JAK2V617F mutation and of its allelic burden has been the objective of intensive research using a variety of cellular and animal models as well as in large series of patients. The second peak of leptin may be the signal of the end of puberty. Addition of the electron donor acetate was used to stimulate a redox profile in sediment columns, from oxic to Fe(III)-reducing conditions. These groups are likely to have diverged in the Pleistocene, corresponding to geological changes and the interglacial-glacial climate oscillations that occurred at the eastern margin of the Qinghai-Tibetan Plateau. The three dimension structure of collagen were changed but not seriously destroyed and the model of photooxidation reaction was validated.

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This review summarizes current knowledge on the role of CD44 in metastasis, as well as the challenges on understanding how this process operates. Since the availability of electronic axiographic tracers, the movement of the condyles can be resolved with high resolution both in space and in time. Efficient cyclic system to yield ectoine using Brevibacterium sp.

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The transfer of the HIV-1PR marker gene could be detected in vivo after intratumoral delivery of the human simplex virus-amplicon vector. Here we approach this problem from the perspective of dynamical systems theory.

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The utilization of high-frequency oscillatory ventilation has dramatically increased in neonatal and pediatric intensive care units. A study of the expression of these genes might allow us to identify the regulatory gene which determines differentiation. Recognition of the injury and identification of the responsible animal is crucial for quick and successful management. Significant downward advection in this bank filtration setting depletes the Mn and Fe oxides in the sediments and enhances the transport of dissolved Fe and Mn into the infiltrating water. To determine the extent of the problem a course evaluation study that measured the knowledge loss of medical students on selected first year courses was conducted.

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MDCK-ras-e cell lines were cloned in vitro from MDCK-ras cell cultures. Of these 400, only the 332 women who did not receive axillary radiotherapy were included in the analysis. The immunopathologic effects induced by two attenuated chicken anemia virus (CAV) isolates, known as cloned isolate 34 (CI 34) and cloned revertant isolate 18 (CRI 18), that were derived from highly passaged pools of Cux-1 CAV isolate, were compared with those induced by a pathogenic, molecularly cloned, low-passage Cux-1 isolate (CI Cux). This report describes laparoscopic superior mesenteric artery first approach, in which the superior mesenteric artery is dissected in the early phase of resection. Toxic effects of polychlorinated biphenyl bioaccumulation in sea urchins exposed to contaminated sediments.

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