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Recently, we found that beta-catenin-LEF/TCF-dependent Wnt signaling stimulates chondrocyte maturation and hypertrophy and extracellular matrix calcification in vitro, events normally associated with cartilage-to-bone transition during skeletogenesis. GDF-9 mRNAs have been shown to be expressed in the human ovarian follicle from the primary follicle stage onward, and recombinant GDF-9 has been shown to promote human ovarian follicle growth in vitro. Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver.

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To determine the equivalence of the proposed alternatives to the standard method, 3 medium/carrier combinations, (1) soil extract nutrient broth/porcelain carrier (current method), (2) nutrient agar amended with 5 microg/mL manganese sulfate/porcelain carrier, and (3) nutrient agar amended with 5 microg/mL manganese sulfate/stainless steel carrier were analyzed for carrier counts, HCI resistance, efficacy, quantitative efficacy, and spore wash-off. Mediastinal lymph node metastasis was found in 64 patients, and 12 patients lived 5 years or more (an absolute 5 year survival rate of 18.8 percent). Electron microscopic and immunohistochemical observations support its non-mesothelial derivation.

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While recommendations for proceeding to clinical trials have been devised in other fields of stroke therapy, such as neuroprotection, no such guidelines exist for preconditioning. Tooth wear is expected to be sex-dependent since energetic requirements and food selection varies largely between sexes in sexually dimorphic ungulates. Preterm labour is a frequent cause of admission to hospital during pregnancy.

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In others, only transient myelolymphodepletion are observed, which are nonetheless sufficient to permit engraftment with fully allogeneic stem cells after otherwise ineffective doses of radiation. Healing of microvenous polytetrafluoroethylene (PTFE) prostheses implanted into the rat femoral vein by means of 3M precise. Both tacrolimus and pimecrolimus prevent disease flares and provide progressive and sustained disease improvement with long-term therapy. We performed a retrospective review of nine patients which included eight patients having ST-elevation myocardial infarction.

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The MCNP4C and experimental data on different source-moderator geometries have been given for comparison. The aim of this study is to evaluate the relationship between left ventricular (LV) wall property and the results of LV volume reduction surgery (LVR) to treat dilated cardiomyopathy (DCM) in an experimental model. Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy. Single-dose formoterol 4.5 or 9 microg delivered by Turbuhaler provided significant prophylaxis against exercise-induced bronchoconstriction compared with placebo, and demonstrated a longer duration of effect than terbutaline, in a randomized, double-blind, crossover trial in pediatric patients (aged 8-17 years).

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Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome. Restriction fragment length polymorphism (RFLP) analysis of the intergenic spacer (IGS) region of rDNA gene was added to further characterize subspecific entities. multiple semen specimens in screening for male infertility factors. The pancreas shows the increased contents of trypsinogen and proelastase and those of lysosomal enzymes (cathepsins and acid phosphatase). Clinical outcome of pediatric collagenous gastritis: case series and review of literature.

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The inhibition of the linoleic acid-induced uncoupling by a purine nucleotide (GTP), was not observed in state 4 respiration, in uninhibited state 3 respiration, as well as in state 3 respiration inhibited by complex III inhibitors. Extracting functional components of neural dynamics with Independent Component Analysis and inverse Current Source Density. Monitoring of polychlorinated dibenzo-p-dioxins and dibenzofurans, dioxin-like PCBs and polycyclic aromatic hydrocarbons in food and feed samples from Ismailia city, Egypt. Use of hyperbaric oxygenation in the overall treatment of hypoxic states in newborn infants

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Foundering of lower island-arc crust as an explanation for the origin of the continental Moho. falciparum proteins were predicted as functional orthologs of known transcriptional regulators in the E. Comparable reduction leaflet flail and regurgitation, and restoration of physiologic leaflet coaptation with the 2 techniques indicate that under acute conditions, use of artificial neochordae or native chordal translocations have similar benefits. The reduction of afterload achieved by the former, the increase of contractility and heart rate induced by the latter, the coronary dilator effect of both, associated with an adequate maintaining of preload proved to be rapidly effective.

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A 49-year-old Japanese woman underwent a total mastectomy, and post-operatively abdominal computed tomography revealed a tumor of the urinary bladder. Rapamycin treatment resulted in the aberrant recruitment of Stat3, Stat4, and phospho-c-Jun to the genomic promoter region resulting in decreased IFN-gamma transcription. When 1 eq of phosphate was incorporated into E2(32kDa), a 2.4-fold activation was also observed for its activity to catalyze the ubiquitination of histone H2A.

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With the exception of the spliceosome and the ribosome, thousands of heterodispersed RNP complexes wherein RNAs are dynamically processed, trafficked, and exchanged are heterogeneous in size and composition, thus providing significant challenges to their investigation. The larger, biologically defined, set of arboviruses contains sub-sets representative of a number of different taxons.

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Papers delivered at the International Workshop on Twin Methodology. The tested formulation at all three dose regimens was also bioequivalent to the reference product in terms of pharmacokinetic profile. Mutations in a permease-like protein of the outer chloroplastic envelope are responsible for the primary biochemical defect.

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While programs are commonly developed around the fields tested as part of the National Voluntary Accreditation Program (NVLAP), the actual fields of application may be significantly different. The human high-mobility group protein A2 (HMGA2) protein is an architectural transcription factor that transforms chromatin structure by binding to DNA. These tendon injuries can result in long-term sequelae, including chronic pain and mobility restrictions, and may warrant surgery.

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Four centers collected normative data for high-pass resolution perimetry. Failure to recognize this facet of arterial anatomy may be one more factor contributing to our inability to successfully revascularize the distal finger in certain patients. The southern pattern revealed incidence rates higher than 15 per 100,000 among males, and the northern pattern displayed lower rate levels. Mutual interaction of vestibular afferent nervous system and vestibular efferent nervous system in vestibular compensation Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking.

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mephitis was studied and compared with type specimens from a naturally infected duck. Neither viremia nor seminal shedding of virus was detected in previously PRRSV-infected, PRRSV-antibody positive boars after challenge with a Danish field strain of PRRSV.

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The platelet adhesion and deformation test indicated that less platelets were adhered to surfaces of all aminolysized specimens than that of both poly benzyl glutamate and polydimethylsilicone. The ophthalmologist can play an important role in the diagnosis of systemic neoplasms that require the intervention of a multidisciplinary team. The present study was designed to determine whether increases in sodium concentration in the cerebrospinal fluid (CSF) play a role in the augmented hypertension induced by long-term salt loading in spontaneously hypertensive rats (SHR), and whether the enhanced arginine vasopressin (AVP) activity and/or the sympathetic nervous system contribute to the increased hypertension. The effects of intravenous cimetidine and metoclopramide on gastric pH and volume in outpatients.

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Viral-mediated delivery of the late-infantile neuronal ceroid lipofuscinosis gene, TPP-I to the mouse central nervous system. It was the study objective to analyse the endogenous thrombin potential (ETP) and related thrombin generation parameters in patients with CAD before the age of 51 in men and 56 in women with and without MetS features and their healthy first-degree relatives. Kortschak: The man, the scientist and the discoverer of C4 photosynthesis.

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This event creates the inflammatory compartment that recruits effector and effector memory CD4 and CD8 T cells, both cognate and noncognate, and macrophage precursors. Computed tomography is valuable in the follow-up and during and after radiotherapy of the tumor. We previously simplified the method by using European Concerted Action on Anticoagulation (ECAA) lyophilized plasma samples with the TAS PT-NC (Bayer AG, Leverkusen, Germany) and the CoaguChek Mini (Roche Diagnostics, Mannheim, Germany) whole blood PT monitoring systems.

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Genetic, biochemical, and bioinformatic data suggest that many PPR proteins influence specific posttranscriptional steps in mitochondrial or chloroplast gene expression and that they may typically bind RNA. Endoscopic ultrasonography was useful in the diagnosis of the tumors. To define the role of a 10-Gy boost to the primary tumor in the conservative treatment of early infiltrating breast carcinoma treated by limited surgery and radiotherapy. In 1 case an inflammatory reaction was observed in the anterior chamber. By studying two groups of patients we present an evaluation of the use of this IVU and the possible replacement by ultrasonography (US).

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The biological role of changes in electro-magnetic fields in the environment of biological systems has scarcely been explored. Interaction of hypoxia and carbon tetrachloride toxicity in hepatocyte monolayers.

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Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. A total of 30 women with PCOS in whom anovulation was resistant to clomiphene citrate received recombinant FSH using the low-dose step-up protocol during only one cycle.

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We report a 20-year-old woman who presented with a painful and non-healing ulcer on the lateral area of the right great toe, which failed to heal despite treatment. Tidal volume and rate of ventilation were, respectively, 3.5-6.6 ml kg-1 and 22-46 b.p.m. SU(5)c-color model single-jet inclusive signatures at the Collider Detector at Fermilab. The authors examined the first 204 consecutive cases from the San Diego Suicide Study, a federally funded investigation of 283 suicides, for possible relationships between suicide and age and the frequency of specific stressors.

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The results indicated that magnolol could significantly inhibit the growth of GBC cell lines in a dose- and time-dependent manner. Myocardial acidosis as reflected in pH measured by a glass (G) electrode during ischemic arrest may adversely affect postoperative cardiac function. We used path analysis to investigate the mechanisms that may produce the observed responses of trophic levels to changes in productivity.

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A report of familial carotid body tumors and multiple extra-adrenal pheochromocytomas. The MP-mediated, cell-to-cell transfer of three human membrane glycoproteins of different degrees of complexity was investigated in the present study, using a CHO cell model system. Data were collected at a Chinese university hospital between August and October 2008.

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Contractile properties of reinnervating skeletal muscle in the rat. Early pulmonary response in rats infected with Trichinella spiralis. Any cases of dysmenorrheal chronic pelvic pain, menstruation and any adverse reactions of patients were recorded once a month during the preoperative and postoperative periods and once every 3 months during the follow-up period.

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In present study, we investigated the role of p38 mitogen-activated protein kinase (p38 MAPK) in the spinal cord in the development of chronic morphine antinociceptive tolerance. Measurement of efficiency of the dialysis sector in Turkey using data envelopment analysis.

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Combining antidepressant therapies from the initiation of treatment: a paradigm shift for major depression. This led us to develop a surgical approach to its cure, which in turn has led to a deeper understanding of the electrophysiologic basis of atrial fibrillation and to the development of a surgical procedure that is highly effective in restoring sinus rhythm with an acceptable mortality and morbidity. Dramatic changes of sulfated proteoglycans composition in a tumorigenic SV-40-transformed renal proximal-tubule cell line. In addition, the stability studies carried out with the inactivated cell culture antigen and the biotinylated monoclonal antibodies stored at room temperature for a period of 180 days revealed that both these reagents yielded consistent optical density values in the ELISA.

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It is recommended that intravenous administration of cimetidine should be an infusion performed over at least 30 minutes. Exogenous Prx6 was administrated intravenously 15 min prior to small intestine ischemia. Women experiencing miscarriage at less than 13 weeks should be offered an informed choice. The present study investigated the effects of treatment on infarct size and enzyme release kinetics in a subgroup of these patients. However, human full-thickness skin, epidermis and cell cultures of human keratinocytes contained significant PNMT activities.

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Expression of bcl-2 gene in human trabecular cells induced by dexamethasone Among the possible mechanisms, changes in the neurotransmission of cardiovascular reflexes have been implicated. Bisphosphonates and teriparatide (recombinant parathyhroid hormone) have recently been approved for use in men and should be considered along with supplemental calcium and vitamin D. Epilepsy centres should be encouraged to report the results of failed epilepsy surgeries.

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In primary molar teeth with exposure of vital pulps by caries or trauma, pulpotomies performed with either formocresol or ferric sulphate have similar clinical and radiographic success. The effects on neuro-transmitters such as catecholamine and indolamine assuming that these derivatives might alter them differently, studied by HPLC-EC method.

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A comparison of predicted human brain concentrations following therapeutic doses demonstrated that varenicline and nicotine, but not dianicline and cytisine, can extensively desensitize and, to a lesser extent, activate alpha4beta2 nAChRs. The fate of a macroporous hydroxyapatite cranioplasty four years after implantation: macroscopical and microscopical findings in a case of recurrent atypical meningioma. In some studies, dietary supplementation of L-arginine reduces atherosclerosis through the restoration of NO release and improvement in endothelial function.

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Cutaneous pseudosarcomatous polyp: a histological and immunohistochemical study. Evaluation included urinalysis, urine culture, cystoscopy and excretory urography in all cases. On the FAD-induced dimerization of apo-lipoamide dehydrogenase from Azotobacter vinelandii and Pseudomonas fluorescens. A cDNA encodes the Drosophila homolog of yeast 60S ribosomal protein YL43.

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gingivalis OMP stimulated PBMCs to express IL-17 at both the mRNA and protein level. The results showed that locally applied antigens of oral microorganisms can stimulate to an immune response both in the lymph nodes and the spleen resulting in circulating antibodies.

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To a similar extent in pinealectomized and sham-pinealectomized rats, a mild stress given by the subcutaneous injection of turpentine oil brought about a greater hypocalcemia after EDTA, concomitantly with a higher PTH secretory response. Moreover, lovastatin-exposed macrophage and BV2 (microglia) in allogeneic MLRs induced the production of the anti-inflammatory cytokine IL-10. The natural history of HIV-1 infection is characterized by persistent viremia, progressive CD4 lymphopenia, and profound immune suppression resulting in opportunistic infections, neoplasms, and death. Both the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. A previously unknown maltose transporter essential for starch degradation in leaves.

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Nervous mechanisms of disturbance of intellectual activity in pathologically excited personalities The ability to convert xylose to xylitol varied among the isolates and ranged from 0.12 to 0.58 g/g xylose.

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Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine. (2) The excited states of D and L molecules are not only parity transformed but time reversed pairs as well.

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PACE labels may be helpful in reducing the number of calories ordered in fast food meals and may have the added benefit of encouraging exercise. All patients with Down syndrome presenting to a tertiary academic pediatric otolaryngology practice over a ten year period from 2002 to 2012 who received tympanostomy tubes for COME, RAOM, or hearing loss were reviewed. OHAs that stimulate insulin secretion weakly or temporally might be useful drug for controlling elderly diabetic patients characterized by post-prandial hyperglycemia.