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We introduced AP-2alpha-specific siRNA (as oligos or in retroviruses) in HeLa or MCF-7 human tumor cells and obtained a pronounced down-modulation of AP-2a mRNA and protein levels. There were 17 bilateral and 3 unilateral cases, for a total of 37 joints.

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1) While positively stained immunoreactive TNF-alpha appeared between 7 and 21 days, no immunoreactive TNF-alpha was observed 1 and 3 days after injection in the nucleus pulposus. More specifically, individuals with benign humor styles (affiliative and self-enhancing humor styles) were evaluated more positively than those targets with injurious humor styles (aggressive and self-defeating humor styles).

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However, the nonlinear patterns of the frequency and the propagation velocity gradients are different. We used gp41 2F5 bnAb germline knock-in mice and macaques vaccinated with immunogens reactive with germline precursors to activate neutralizing antibodies. Rab GTPases play key roles in the delivery, docking and fusion of intracellular vesicles.

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Could adding magnesium as adjuvant to ropivacaine in caudal anaesthesia improve postoperative pain control? For this purpose we identified several antigenic determinants--the fragments of CDF, and the following peptides were synthesized--P41-52 H-Leu-Glu-Thr-Arg-Gln-His-Arg-Leu-Phe-Cys-Ala-Asp-NH2, P53-60 H-Pro-Lys-Glu-Gln-Trp-Val-Lys-Asp-NH2 and P60-71 H-Asp-Ala-Met-Gln-His-Leu-Asp-Arg-Gln-Ala-Ala-Ala-NH2.

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Septic complications after low anterior rectal resection--is diverting stoma still justified? In addition, the main chain conformation of the beta5 strand, which forms a hydrophobic core with Trp81, was found to be important for the fibril formation by CAD-CD. Coumarin is worthy of further consideration as an agent for use in controlling the normal and abnormal growth of the prostate. Rather, the task appears to aid and isolate the effects to the muscle groups involved in the task. However, toxicity caused by pyrolysis products may occur during combustion in homes insulated with either type of insulation.

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The serotype distribution of Campylobacter in patients with diarrhoea in Kuwait. Hypercholesterolemia further impaired the depressed LV function in rabbits post-MI. Alcoholic women generally had a lower degree of atherosclerosis in the aorta. Anxiety-like behavior and locomotion in CCK1 knockout rats as a function of strain, sex and early maternal environment. Decomposition and arthropod succession in Whitehorse, Yukon Territory, Canada.

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Contrast can be significantly improved and patient dose reduced if more efficient methods of scatter control can be developed. In CKD, higher plasma CXCL12 was associated with CVD risk factors and prevalent CVD as well as the hazard of incident MI and death. Recurrent ventricular catheter obstruction and SVS can be prevented by prophylactic supplementation of every shunt system with an ASD. Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. The observed asymmetric spectral shape of the Soret band was analyzed using a configuration-coordinate model.

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Tissue plasminogen activator in the percutaneous drainage of splenic abscess. Further studies are required to determine the causal association, if any, between iron excess and primary psychiatric illnesses. This multicenter study sought to determine whether differences in ANCA epitope specificity explain why, in some cases, conventional serologic assays do not correlate with disease activity, why naturally occurring anti-MPO autoantibodies can exist in disease-free individuals, and why ANCA are undetected in patients with ANCA-negative disease.

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These results indicate that P-21 inhibits the OxLDL-induced macrophage proliferation through binding of P-21 to OxLDL. Here, we report the fine mapping and candidate gene analysis of RppP25 from the near-isogenic line F939, which harbors RppP25 in the genetic background of the susceptible inbred line F349. Evaluation of preventive measures for mother-to-child transmission of HIV in Aracaju, State of Sergipe, Brazil. However, the size-dependent synergistic effects of envelopment and internalization as well as the metabolic mechanisms of nanomaterials have remained unknown.

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Magnetic state of poly(m-toluidine): Dependence on absorbed water. The role of sequence-specific binding proteins in transcriptional control in higher eukaryotes is unclear.

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Theory for the effects of impurities on the Raman spectra of superconductors. Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells.

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Postoperative management of pain after total joint arthroplasty remains a challenge despite advancements in analgesics. Activation of the alternative pathway of complement by microcrystalline cholesterol.

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The cyanide-metabolizing enzyme rhodanese in human nasal respiratory mucosa. A cyclic metallopeptide induces alpha helicity in short peptide fragments of thermolysin. Research note: utility of the thiobarbituric acid test in the determination of the quality of fats and oils in feeds.

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These findings provide further support for the survival processing effect and extend the observed effect duration for both word lists and location to 96 hours. These assays might be able to resolve indeterminate anti-HIV Western blot results. 6 patients were reviewed by the same surgeon, 6 patients were examined clinically and with ankle X-rays. Recently, new finding of a kinin receptor has been reported, since specific kinin receptor antagonists have become available.

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Programs focusing on early defibrillation have improved both short- and long-term survival of patients with VF out-of-hospital cardiac arrest (OHCA). On the mechanisms of oxidation of organic sulfides by H2O2 in aqueous solutions. A mechanism by which ethanol could stimulate RA synthesis is via the ethanol-activated short-chain retinol dehydrogenases, which we show to be present in the postnatal cerebellum.

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Stress-protective effect of the synthetic ACTH-like peptide leucocorticotropin Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. Although clinical research efforts into the use of these agents as substitutes for blood transfusions continue at present, the rapid disappearance of emulsified FCs from the vascular space and accumulation in the liver and spleen may well limit their usefulness as transfusion substitutes. The strains could be grouped into two main clusters colligating the isolates from ground water and surface water samples. The EMG response of the puborectalis muscle to straining at different pressures was recorded.

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She was then diagnosed with refractory inflammatory pseudotumor, and subsequent treatments included several mastoidectomies, further steroids, and radiation therapy. In a small, but probably underestimated proportion, HF is caused by Mendelian inherited forms of myocardial disease.

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The results confirm the selectivity of Selectikine with predominant T-cell and low NK cell activation, supporting follow-up studies assessing the clinical efficacy of Selectikine for cancer patients. In this article, the author suggests how college health nurses, in everyday practice, can seize opportunities for helping students face their alcohol-related problems. This result could be accounted for by a direct action of GSH on viral replication. Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia.

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Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. Since individual clinicians usually have a preference, most trials could be judged unethical according to this line of argument.

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Coronal CT sections were particularly useful in demonstrating the relationship of the tumor to the porta hepatis, pancreas and duodenum. Human chromosome 8 randomly marked with neo gene was introduced into highly metastatic rat liver cancer C5F cell line by treating the single human chromosome donor cells with sequential steps of micronucleation, enucleation and microcell fusion. Our binary holograms yield reconstructed images of a quality equal to that of images obtained from usual holograms of comparable dimensions. At baseline, all subjects underwent neuropsychological tests, Neuropsychiatric Inventory (NPI), and MRI.

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The use of electronic data processing in radiologic practice-- possibilities and uses as exemplified by SISYMED from Siemens Nixdorf Informationssysteme AG The samples were subsequently cultured on blood agar and EMB plates and the colonies were counted. The isotherm parameters determined for single components were used to simulate the competitive adsorption equilibria through the IAS (ideal adsorbed solution) theory.

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Groups I and IV animals received starch-based control diet, while groups II and III rats were fed a high fructose-diet (60 g/100 g). Raccoon roundworm eggs near homes and risk for larva migrans disease, California communities. Infected pupae with mycelium had higher survival rates than infected pupae without the cover, although this depended upon the time at which adult sister workers were allowed to interact with pupae. We found no significant differences in tooth movement between the patient with MFS and healthy subjects.

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Clinical statistics of endogenous uveitis: comparison between general eye clinic and university hospital. The contribution of MRP1 expression to a reduced DNR accumulation seems minor compared to Pgp. The prevalence of each histological subtype was calculated from the pooled cases. Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disease of uncertain etiopathogenesis commonly associated with inflammatory bowel disease (IBD) and is characterized by patchy inflammation of the biliary tree progressing to fibrosis and strictures. We present a case of diffuse cutaneous leishmaniasis in a senegalese patient with HIV 1 infection.

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Strains carrying dominant SRB mutations have the same suppression properties as a sca1 delta ::hisG strain. Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors.

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To evaluate and compare the early pregnancy (11-14 week of gestation) serum level of angiogenic proteins sFlt1, VEGF i PIGF between different types of pregnancy related hypertensive disorders. Doses of rosuvastatin, atorvastatin and simvastatin that induce equal reductions in LDL-C and non-HDL-C: Results from the VOYAGER meta-analysis. Growth cone guidance during development, as well as axonal extension in neural repair and plasticity, is strongly regulated by both attractive (growth-promoting) and repulsive (growth-inhibiting) guidance molecules. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.

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Genetically determined variability in appetitive traits may be one of the pathways through which genes influence the growth rate in infancy. A number of solutions have been recently described to deal with this limitation, among which stands the possibility to record several interleaved scans. Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma. Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes. All the distant metastatic lesions were confined to the right side of the body.

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MSNA burst amplitudes were measured during the OFF periods and BOLD signal intensity was measured during the subsequent 4s period to allow for neurovascular coupling and nerve conduction delays. bifidum BGN4 had a novel composition, comprising chiroinositol, rhamnose, glucose, galactose, and ribose. Cyclic fatty acids: natural sources, formation during heat treatment, synthesis and biological properties. Towards characterization of epidermal cell migration promotion activity in serum.

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Subjects were included in this study only if they showed a good clinical response during the trial. Despite the close structural similarity to NO, defined biological roles and endogenous formation of HNO remain unclear due to the high reactivity of HNO with itself, soft nucleophiles and transition metals. Identified patients were evaluated for relevant disorders, including genetic testing for a 3-base pair deletion in APOE that causes deletion of leucine at position 167 of apolipoprotein E. The integration of 4D-flow and T1 -mapping-MRI allowed for the evaluation of tissue and flow abnormalities in HCM patients. Effect of elevated triglyceride levels on endothelium-dependent vasodilation in patients with hypercholesterolemia.

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GREAT-a randomized controlled trial comparing HydroSoft/HydroFrame and bare platinum coils for endovascular aneurysm treatment: procedural safety and core-lab-assessedangiographic results. An OLED device of single Ga2(saph)2q2 layer exhibiting desirable performances has been fabricated, which is in good agreement with the theoretical analysis. The effect of combined treatment with dextran 40 and acetylsalicylic acid on patency in severely traumatized small veins and arteries: an experimental study in the rabbit.

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Anti-IL-6 treatment may provide a new potential target for treating allergic asthma. MEDLINE (1966-2001) and EMBASE (1950-2001) were searched for studies on the incidence of DVTand thromboembolism in the general population. TMEM5 is a UDP-xylosyl transferase that elaborates the structure. To determine the frequency of genomic copy number aberrations of SPAST in autosomal dominant HSP.

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We conclude that Merkel cell tumours behave in a similar manner to the aggressive variants of melanoma and that minimal treatment consists of wide surgical resection of the primary lesion (with a margin of 2.5-3 cm) coupled with resection and probably also radiation of regional disease if present. A series of validation experiments was carried out to assess robustness, repeatability, and trueness of an analysis procedure for simultaneous determination of (226)Ra and (228)Ra in water samples.

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Natural killer (NK) activity in rats and NK and antibody-dependent cell-mediated cytotoxicity in mice have been shown to be rapidly augmented by in vivo treatment with a variety of viruses and immune adjuvants. Continuity of electron histochemically demonstrable substances in the basal lamina, the ground substance of the connective tissue and the intercellular spaces of eptihelial cells of rat gingiva.

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Western blot analysis was used to evaluate the protein levels of Elf-1 and survivin in 17 specimens of NSCLC and 5 specimens of normal tissue. In autoimmune diabetes, mucosal vaccination with autoantigens was frequently effective in restoring tolerance in mice but has not yet succeeded in humans.

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There appears to be an elevated risk of family history of substance use disorders in MOH patients, and an increased risk of MOH in patients with diagnosed personality disorders. Support for this comes from several lines of animal research: (1) GABA antagonist-induced priming of anxiety states, (2) extinction of conditioned fear, (3) modulation of inhibitory avoidance memory, and (4) cue-induced reinstatement of drug seeking. In vitro activation of distinct molecular and cellular phenotypes after induction of differentiation in a human neuroblastoma cell line. Intrathecal catheters were implanted in age-matched normal and diabetic rats. To investigate the physiological function of sulfated polysaccharides in M.

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Longitudinal assessment of blood-brain barrier leakage during epileptogenesis in rats. Nasal Mucosal Expression of the Receptors for Inflammatory Chemical Mediators.

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Proteins deleterious on overexpression are associated with high intrinsic disorder, specific interaction domains, and low abundance. Caught in the middle: apical ballooning syndrome with dynamic mid-ventricular obstruction. An identification of the novel combination therapy for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells.