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Karum (Clopidogrel)
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Clopidogrel

Karum bisulfate (Karum) is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Karum prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other drugs in this class include ticagrelor (Brilinta) and prasugrel (Effient). Karum is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Unlike ticlopidine, Karum bisulfate does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack, and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking.) Karum bisulfate is used to reduce the risk of heart attacks and strokes in these patients. Karum bisulfate was approved by the FDA in 1997.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

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Platelet function disorders are a rare cause of bleeding in hematological practice. SF-36 may also be a promising measure for research on health inequalities in Turkey and other developing countries. The expression levels of bacterial genes can be measured directly using next-generation sequencing (NGS) methods, offering much greater sensitivity and accuracy than earlier, microarray-based methods. In a few countries the prophylactic approach of the menopausal osteoporosis has been already introduced. Overall Q allele frequency was 0.14, with no differences between obese and nonobese individuals (0.15 vs.

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Lexical and semantic ability in groups of children with cochlear implants, language impairment and autism spectrum disorder. At the dose level greater than 2.0 g/m2/day for 5 days, the mean serum 5-FU values appear over the therapeutic range (0.1 micrograms/ml). Cacospongionolide B inhibited nuclear factor-kappaB (NF-kappaB)-DNA binding activity and the nuclear translocation of this transcription factor.

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We propose that Mdm33 is involved in fission of the mitochondrial inner membrane. Eleven male participants were tested under white-noise random vibration input signals at the seat level with a frequency range of 0.5-10Hz and magnitudes of 1.5m/s(2) RMS for the fore-aft condition and 1.0m/s(2) RMS in each direction for the combined-axis condition.

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Resistance to quinupristin-dalfopristin is rare among staphylococci in the United States, and resistance to linezolid is very rare. Diabetes mellitus involves vascular inflammatory processes and is a main contributor to cardiovascular mortality. The gamma rays or gamma quanta are detected by using gamma cameras. Benign positional vertigo, the most common cause of vertigo, can now be cured with a simple bedside maneuver. Missense mutations in the coagulation factor C homology (COCH) gene (14q12-q13) cause the autosomal dominant sensorineural hearing loss and vestibular disorder DFNA9 (OMIM 603196), and a high prevalence of symptoms of Meniere disease (MD) has been described in families with a mutation in the COCH gene.

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Supernatant VWF concentration and multimer structure were measured, and platelet-VWF strings formed on the endothelial surface under flow were quantified. The simultaneous use of two or more techniques, contrast reagents, signalling methods, or the coupling of agent and tissue properties to achieve so-called multiplexed imaging is a promising approach.

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Despite of this major clinical relevance, only low throughput, time and labor intensive methods have been used so far for the quantification of C4A and C4B genes. Both qualitative and quantitative assessment were performed as well as a sensitivity analysis to the segmentation error. Galileo and Descartes on Copernicanism and the cause of the tides. These observed effects of carbofuran on the estrous cycle and follicles may be due to a direct effect on the ovary or the hypothalamo-hypophysial ovarian axis causing hormonal imbalance.

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Two-dimensional echocardiography has disclosed concentric ventricular hypertrophy and the typical findings of congestive cardiomyopathy. Among the SFKs, Lyn is predominantly phosphorylated and Lyn-specific small interfering RNA inhibited the growth of B lymphomas, supporting an important role for Lyn in B lymphoma growth. (Myrothamnaceae) was fractionated by a combination of CC on Sephadex LH-20, MPLC on RP-18 material and LPLC on MCI-gel. Transport into the disc for each loading regimen was quantified using post-contrast-enhanced magnetic resonance imaging. Exposure to CM did not influence case fatality, ability to live at home, ability to walk, disability and stroke severity.

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Genetically distinct inbred strains of mice that differ in their susceptibility to mouse cytomegalovirus (MCMV) are invaluable for dissecting complex host-pathogen interactions. This developmental program is determined by cues emanating from the somatic environment. To compare the efficacy and complications of extracorporeal shock-wave lithotripsy (SWL) and pneumatic ureteroscopic lithotripsy (URS) in the treatment of lower ureteral calculi. The core thesis is that once the patient with orthopaedic problems initiates litigation, he or she starts to become invested in permanent disability, and the slide down the slippery slope of a lifetime of disability has begun.

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Comparative genomic analyses in this study demonstrated genetic similarity among AEEC plasmid genes involved in plasmid replication conjugative transfer and maintenance, while the remainder of the plasmids had sequence variability. Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo. Utilization of dietary protein depends not only on the amino acid composition and the digestibility of the protein itself, but also upon the level of protein, feed intake, energy, fibre, and other constituents in the feed. The activities of these enzymes were monitored by reverse phase high performance liquid chromatography, and the intermediate products formed were characterized by 1H and 13C nuclear magnetic resonance spectroscopy analysis. Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices.

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The guidelines were controversial and their implementation incomplete. A new series of aza-substituted analogues 3-5 based on the 1,4-bis(phenylethynyl)benzene moiety have been synthesized by the selective Pd-catalyzed Sonogashira coupling reaction from 5-bromo-2-iodopyrimidine (1). The forced oscillation technique was used to measure the resistance (Rrs) and the reactance (Xrs) of the respiratory system at frequencies ranging from 4 to 26 Hz. For the present study a total of 1,069 Developmental Record protocols were obtained from archival files of a large midwestern facility for mentally retarded persons.

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Inferior mesenteric artery embolization before endovascular aneurysm repair: technique and initial results. Extracorporeal membrane oxygenation in the perioperative period of heart transplantation.

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Our results suggest that p75NTR may not be a critical molecule mediating the function of myelin-associated inhibitory factors in vivo. Flapless surgery based on FRP-supported image-guided surgical templates may provide similar accuracy as reported for tooth-supported surgical templates or surgical navigation.

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Attention deficit hyperactivity disorder (ADHD) is an increasingly common diagnosis of childhood that manifests with symptoms that affect cognitive, academic, behavioral, emotional, and social functioning. The treatment effect of NSAIDs/coxibs was relevant in the subgroup of patients with increased CRP at baseline. Does a hypertonic saline load predict fluid retention in pacing induced heart failure? A subgroup of the men on the high-sodium diet also received 100 mmol potassium/day.

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Four alternate sets of van der Waals parameters for the oxygen types of the GROMOS force field that have been suggested by different authors are then tested against the original force field. A two-year clinical follow-up of 170 crowns has shown that such crowns are in full accord with the esthetic, functional, and biological requirements of dental prosthetics. An ultrasonic scanner is described that can be used for transurethral as well as for transrectal scanning of the bladder, the prostate and the seminal vesicles. When the sympathetic stimulation was 6 Hz, vagal nerve stimulation at 5 Hz decreased dP/dtmax by 513 mmHg/s and reduced dP/dtmin by 709 mmHg/s.

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Our results showed that detectable level of sHLA-G is not produced by day 2 embryos and such a measurement may not provide reliable information for embryo selection and estimation of pregnancy success. The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase (MPO) activity, IL-6 and apoptotic incidence. Fruit and vegetable polyphenols also offer great potential, although most research thus far has involved rodents. Fatty acid metabolism is an attractive route to produce liquid transportation fuels and commodity oleochemicals from renewable feedstocks. A case of popliteal artery entrapment syndrome with chronic total occlusion.

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Investigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. The evidence suggests that brain penetrant-CRF(1) receptor antagonists have therapeutic potential for alcohol dependence. The antioxidants that inhibited cytotoxicity in vitro were then studied also in vivo. However, the pathophysiological function of PSTPIP1 remains to be elucidated. This study indicated that the mutations and deletions of FHIT gene in PJS may play a role in the development of PJS and their cancerations.

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Hyperdopaminergic crises in familial dysautonomia: a randomized trial of carbidopa. Evaluation of the effects of mivacurium chloride on hemodynamics and left ventricular function in patients with coronary artery disease undergoing abdominal aortic surgery.

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We show the possibility of detecting small anisotropies in holographic polymer dispersed liquid-crystal samples, using a simple experimental setup that allows us to determine the behavior of the diffraction efficiency versus incident angle for two reading polarizations. Physician groups have supported the prescription benefit within the Medicare reform package. bovis or surviving organisms in macrophages that use the intracellular survival as a strategy for evasion of the immune response. Incubation with the drugs decreased endothelial cell migration whereas addition of YC-1, SC and 8Br-cGMP recovered the effect. Partial least squares (PLS) and the machine-learning technique Kriging generated validated models.

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Morphological structures and protrusive cranial border guidance of the temporomandibular joint of Cercopithecus mona. The data indicate the majority of patients are satisfied with the results of the procedure. Adverse contact reactions to sculptured acrylic nails: 4 case reports and a literature review. In 1976, in conjunction with the practicing surgeons of a large, referral hospital, the Infections Control Committee instituted surveillance of selected clean surgical procedures and deep-versus-superficial wound infections.

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E-type asteroid (2867) Steins as imaged by OSIRIS on board Rosetta. Posttranslational processing of the neurotensin/neuromedin N (NT/NN) precursor has been investigated in mouse brain and small intestine by means of region-specific radioimmunoassays coupled to chromatographic fractionations. The response to therapy of inflammatory processes in the conjunctiva seemingly differs from the response in the cornea.

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Ephrins A1 and A5 are substrates for a cross-linking enzyme, tissue transglutaminase, which mediates the formation of oligomeric ephrin. Sustainable myocardial recovery after mitral reconstruction for left ventricular noncompaction.

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Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: a preliminary study. Its frequency has increased in recent years due to its common association with Human Immunodeficiency Virus (HIV) infection and the growing recognition of new etiologic agents such as drugs and parvovirus B19. Cytotoxicity of NMDA on rat cerebrocortical slice cultures was potentiated by addition of glycine or d-serine.

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The complications, blebs, intraocular pressures(IOP), and visual acuity were observed postoperatively. The TPs were tentatively identified by high-resolution mass spectrometry (HR-MS) to be irgarol sulfoxide and terbutryn sulfoxide. We report a rare case of metastatic renal cell carcinoma involving the nose and ethmoid sinus, 17 years after initial nephrectomy and diagnosis of Stage T1N0 clear cell renal cell carcinoma.

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Moreover, MR overexpressing and control mice discriminated equally well between fear responses in a combined cue and context fear conditioning paradigm. The best improvement was recorded in attention, visuospatial and intellectual functions. The conserved bifactorial endosperm box found in the promoter of wheat storage protein genes comprises two different cis elements that are thought to be involved in regulating endosperm-specific gene expression. Using high-resolution finite element modeling of a cohort of elderly vertebrae, we found that the biomechanical role of the shell can be substantial and that the load sharing between the cortical and trabecular bone is complex. Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation.

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We hope this work will invite and advance dialogue among public health practitioners and decision makers to build and strengthen a diverse evidence base for public health programs and strategies. Oral lichen planus: diagnostic immunofluorescence testing on routine histological material.

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Serum level of secretory endometrial protein PP-14 in intact ectopic pregnancy. Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites. A special attention is paid to the peculiar situation of the premature, and also to the modifications needed in the therapeutic schedules for serious neonatal infections. Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating. Responses of DNA and DNA-CTA complex to an elongational flow field were investigated.

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It has been hypothesized that diminished arterial pressure and flow pulsatility delivered by CVAD may be a contributing factor to these adverse events. We report here on the frequency of three CHEK2 variants that alter protein function--1100delC, R145W, and I175T--in 506 cases and 459 controls from a population based, case-control study of breast cancer conducted in young women from western Washington. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship.

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Malformational complex in an infant with intrauterine influenza viral infection. Chronic persistent asthma is characterized by poorly reversible airway obstruction. Mechanical treatment of periodontitis (scaling and root planing), when combined with short-term administration of therapeutic levels of tetracycline-type antimicrobials, can temporarily improve glycemic control in diabetic patients, especially in those with advanced forms of periodontitis and poor glycemic control before treatment.

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Since lower educational level and more restricted employment opportunities characterize disability pensioners as compared to the nation, it seems likely that more varied occupational rehabilitation and educational opportunities could improve the situation of those who have had to leave the labour market because of ill health, lack of education and poor working conditions. Capsular sack implantation of heparin-modified posterior chamber lenses Foldable polymers with alternating single-strand deoxyribonucleic acid and planar conjugated organic perylene tetracarboxylic diimide units were found to self-organize into loosely folded nanostructures.

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Inference of gene-regulatory networks (GRNs) is important for understanding behaviour and potential treatment of biological systems. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA expression and protein secretion of apolipoprotein E, apolipoprotein A-I, and apolipoprotein A-IV in early primary cultures of lipocytes, hepatocytes, and Kupffer cells. The patient underwent a salpingo-oophorectomy and resection of the intestinal segment, took antibiotics and recovered. Cytogenetic analysis demonstrated a duplication of chromosome sub-region 7p21.2-p14.2. A site on rod G protein alpha subunit that mediates effector activation.

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Susceptibilities to different antibiotics of Helicobacter pylori strains isolated from patients at the pediatric medical center of Tehran, Iran. The early decrease in the endothelial cells of the cerebral vessels of rats after local irradiation Most reported cases of toxic shock syndrome have occurred in young menstruating women and have been associated with the use of tampons. HRQOL measurement in young people is still in its developmental e 53 pill quetiapine step. InfoSyll: a syllabary providing statistical information on phonological and orthographic syllables.

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Profound advances in biomedical science have contributed to increased longevity and improved quality of life for many Americans. The unique properties of brain endothelial cells, which form the blood-brain barrier, are reflected by the expression of specific cell surface molecules. Our results identify a previously unidentified metabolic pathway from NaAD using unprecedented carboxylase and sulfur transferase reactions to form the organic component of the (SCS)Ni(II) pincer cofactor of LarA. Uninvolved skin of patients did not differ from that of healthy volunteers. It may be mutation, inappropriate or incomplete cleavage, overproduction, pantoprazole injection administration codes or the availability of a template for misfolding.

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Development and Validation of a Universal High-Throughput UDP-Glycosyltransferase Assay with a l oroken antibiotic Time-Resolved FRET Signal. Cocaine-induced enhancement of motor activity and extracellular dopamine concentrations exhibits sensitization upon repeated exposure. Since the orthodontist is frequently the first clinician to be consulted for dentofacial deformity, an awareness of potential surgical procedures available to correct such deformities is imperative. Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells.