on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Iscover (Clopidogrel)

Iscover is used to prevent blood clots if you have chest pain, peripheral artery disease (poor circulation in your legs), a heart attack, or stroke. This drug may be used as part of a combination therapy. That means you may need to take it with other drugs. Your doctor will decide if you should use this drug with other drugs, such as aspirin.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

Similar Products:
Valacyclovir, Triomune, Candistat, Rulide, Noritren, Amineurin, Itrin, Medibiox, Quetiapin, Ciazil, Buspin, Warfarina, Sildenafilo, Vermox, Blistex, Viaclav, Oropram, Finara, Syneclav, Duloxetina, Klarimax, Metrazol, Gabateva, Clopicard, Setrobuvir, Zurcal, Atazor, Klabion, Heviran, Ogastro, Nobactam, Amoxydar, Linaris, Pandon, Cycline, Gabax, Augmentin, Dumocycline,

iscover 75mg side effects

This study captures the peculiar motion of Eutreptiella gymnastica with simple force distribution. We reviewed the records of 1030 patients with estrogen receptor-positive, HER2-normal stage I breast cancer and RS available. No patient developed intravascular coagulation or activated fibrinolysis during heparin treatment. We illustrate our results for the case of two-dimensional Rashba spin-orbit coupling in a Zeeman field. Nonmelanoma skin cancer is one of the most common malignancies in humans.

iscover 75 mg preisvergleich

Radiological diagnosis of IHL is possible in a majority of cases, but sometimes features may overlap with hepatoblastoma and fine needle aspiration may be performed inadvertently. Mandatory influenza vaccination for health care workers as the new standard of care: a matter of patient safety and nonmaleficent practice. Food was cooked once a day, which meant food was contaminated by flies throughout the day. Antioxidant lignans and chromone glycosides from Eurya japonica. At the time of distant relapse, biopsy was repeated for molecular characterization.

iscover clopidogrel tablets 75 mg

The effect of market reform on racial differences in hospital mortality. They may be due to underlying infectious, autoimmune or neoplastic processes, although most of the cases reported in recent years have no base pathology and are known as idiopathic hypertrophic pachymeningitis. Serotonin has been recognized as a potent mitogen for a variety of cells and tissues. Aspirin intake following colorectal cancer resection was associated with a significant improvement of survival in patients whose tumors carried mutant, but not wild-type, copies of the phosphoinositide 3-kinase (PI3KCA) gene, especially tumors that overexpressed COX-2.

iscover 75 mg side effects

Recent studies on genome-wide association have identified common variants on chromosome 9p21 associated with coronary artery disease (CAD). X-ray-reflectivity study of the growth kinetics of vapor-deposited silver films. In the light of recent developments within the health services, this inequitable provision of continuing professional education to all nursing practitioners will need to be addressed and resolved.

nebenwirkungen iscover 75 mg

The dynamics of changes in the main parameters of the culture, such as luminescence, growth, respiration, heat emission etc., was investigated. We investigated the mechanisms responsible for paclitaxel resistance in HME-1 cells (human mammary epithelial cells immortalized with hTERT). A large cassette, 4.6 x 10(3) bases (4.6 kb) in length, containing an inducible expression system (the yeast CUP1 promoter fused to the Escherichia coli lacZ structural gene) and a bacterial neomycin-resistance gene (neo) has been cloned into the noncoding region of a GAL1-regulated Ty1 retrotransposon.

nebenwirkungen iscover 75 mg

The Stockholm Water Company has tested various ways of treating stormwater. Both cationic and anionic PAMAM dendrimers internalized within 20 min, and differentially colocalized with endocytosis markers clathrin, EEA-1, and LAMP-1. Two out of 29 carbon sources tested interfered with fumagillin biosynthesis.

iscover 75 mg wirkstoff

Type of distribution of the test data of the optokinetic nystagmus. Post-operative chemotherapy consisting of cyclophosphamide, vincristine, adriamycin, dimethyl triazeno-imidazole carboxamide (CYVADIC) was performed and the patient is doing well without any evidence of recurrence or metastasis. The aim of our study was to determine serum levels of zinc and copper in mothers of children with non-syndromic orofacial clefts and in women who gave birth to healthy children. Optimization was performed on scanning timings and doses using the D-optimality criterion. Samples of experimental silicone rubber were surface modified by first argon plasma treatment followed by chemisorption of ethyleneoxy functional silanes.

iscover 75 mg preis

The finding of proteinaceous ascitic fluid and hepatic histologic features of centrizonal sinusoidal congestion suggested hepatic venous outflow obstruction. The microcirculatory bed of the myocardium in experimental embolism of the branches of the pulmonary artery Initial dyscirculatory encephalopathy in middle-aged and elderly patients (problems of early diagnosis and therapy)

iscover 75mg side effects

Correlations between ER clones 1D5, SP1, F10, and ER60c, and EGFR monoclonal 31G7, 2-18C9, H11, and 15F8, and polyclonal 2232 antibodies were assessed in 642 breast cancer patients. Tissue factor (TF)-producing cells were identified in normal human vessels and atherosclerotic plaques by in situ hybridization and immunohistochemistry using a specific riboprobe for TF mRNA and a polyclonal antibody directed against human TF protein. The search for these missing elements led to the discovery of isopentenyl phosphate kinase (IPK), one of two activities necessary to furnish the universal five-carbon isoprenoid building block, isopentenyl diphosphate (IPP).

iscover 75mg filmtabletten

Prognostic usefulness of echocardiographic dobutamine in younger (14 to 25 years) and older (40 to 55 years) patients with idiopathic dilated cardiomyopathy. A life-threatening case of disseminated nocardiosis due to Nocardia brasiliensis.

iscover 75mg filmtabletten

Costs, availability and ease of use often dictate the local and regional differences in imaging approach, whether ultrasound, CT, or MR. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. In endometrial carcinoma cells, the production of progesterone also increased with over-expression of StAR and the F2 system.

iscover 75 mg beipackzettel

Ascertainment of the adenoma subtype may become an important consideration in the management of acromegaly. It needs to be recognized that most inferences drawn in our study rely on a limited number of studies, potentially, endangering the generalizability of our findings. AZF microdeletions associated with idiopathic and non-idiopathic cases with cryptorchidism and varicocele. Measurement of personal competence of mentally retarded individuals. When the lipoproteins obtained from the non-recirculating perfusate were injected into rats in vivo, the half life of the VLDL was 13 min and most of it was converted to LDL, while that of the LDL was 5.2 h, indicating that the perfusate LDL was different from the VLDL with respect to its metabolic fate.

iscover clopidogrel 75 mg

The therapy had to be stopped on account of pyoderma gangrenosum and exacerbation of psoriasis in spite of a biochemical response to the therapy for hepatitis C. Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats. Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger. Additionally, FA in mite-infected flies generally did not differ from previously published FA data from uninfected S.

iscover 75 mg preis

  • prasugrel vs clopidogrel pptx
  • iscover 75 mg beipackzettel
  • iscover 75 mg precio
  • blood thinning drugs clopidogrel 75mg
  • pidovix clopidogrel 75 mg
  • clopidogrel mode of action ppta
  • iscover 75 mg preisvergleich
  • black box warning fda clopidogrel
  • iscover 75mg filmtabletten
  • nebenwirkungen iscover 75 mg
  • aspirin and clopidogrel bilayer tablets with keyboards
  • iscover 75 mg side effects
  • clopidogrel al 75 mg filmtabletten stada
  • rezistencija na clopidogrel generic
  • rezistencija na clopidogrel tablets
  • mechanism of action of clopidogrel on platelets definition
  • iscover 75 mg clopidogrel
  • mechanism of action of clopidogrel bisulfate plavix
  • clopidogrel 75 mg r 196
  • mhra drug safety update clopidogrel mechanism
  • iscover 75mg side effects
  • mode d action du clopidogrel recall
  • clopidogrel hexal 75 mg filmtabletten
  • sarpogrelate clopidogrel tablets
  • iscover 75 mg nebenwirkungen
  • clopidogrel missed doses
  • generic clopidogrel bisulfate 75-mg tablets android
  • iscover 75 mg para que sirve
  • clopidogrel side effects stroke
  • iscover 75 mg filmtabletten nebenwirkungen
  • price of clopidogrel 75 mg uk parts
  • clopidogrel reversal desmopressin spray
  • clopidogrel bisulfate plavix cost
  • iscover 75 mg in china
  • clopidogrel mechanism of action wikipedia
  • iscover clopidogrel tablets 75 mg
  • prescribing proton pump inhibitors with clopidogrel medication
  • prasugrel vs clopidogrel vs ticagrelor 90
  • blood thinning tablets clopidogrel 75mg
  • medicamento iscover 75 mg
  • p2y clopidogrel tablets
  • ticlid vs clopidogrel 75mg
  • clopidogrel ttp symptoms of pancreatic cancer
  • clopidogrel impurities synthesis protein
  • prasugrel effient vs clopidogrel plavix
  • mhra drug safety update clopidogrel medication
  • iscover 75 mg preis
  • clopidogrel bioequivalence study fda
  • teva-clopidogrel 75 mg
  • clopidogrel plus aspirin tablets ingredients
  • interaction clopidogrel ciprofloxacin
  • clopidogrel maintenance dose
  • clopidogrel bisulfate 75mg tab
  • aspirin versus clopidogrel stroke
  • clopidogrel dosage and administration
  • estudios bioequivalencia clopidogrel generic
  • onset offset ticagrelor vs clopidogrel
  • iscover 75 mg vademecum
  • clopidogrel side effects cats
  • aspirin clopidogrel interaction with proton
  • clopidogrel 75 mg
  • varenhorst clopidogrel generic
  • antiplatelet action of clopidogrel 75mg
  • clopidogrel 75 mg uso stock
  • iscover 75 mg wirkstoff
  • precio de iscover 75 mg
  • site of action of clopidogrel 75mg
  • pidogrel clopidogrel medication
  • clopidogrel side effects cough
  • iscover clopidogrel 75 mg

clopidogrel hexal 75 mg filmtabletten

The selectivity for the sequence corresponding to position 990 in pBR322 is maintained even when this site is located only 15 bp from one end of the 147 bp fragment. The consensus of scientists is that exposure to radon is hazardous, but disagreement exists about the effects of lower radon concentrations.

clopidogrel bisulfate 75mg tab

We then turn to the cognitive level and the characterization and workings of fairness. Melasma is a commonly acquired symmetrical hypermelanosis on sun-exposed areas of the skin. Stimulation of the perineal muscles produced a stronger inhibition of the RMCs than that of the perineal skin. Total left ventricular outflow tract obstruction due to left ventricular assist device-induced sub-aortic thrombosis in 2 patients with aortic valve bioprosthesis. We have studied the effect of the Dictyostelium discoideum 30,000-D actin-bundling protein on the assembly and disassembly of pyrenyl-labeled actin in vitro.

clopidogrel 75 mg uso stock

No accurate definitions of baseline healthy status and/or clinical outcomes were provided. Like MRK-16 combined with CsA, MRK-16 enhanced the effect of a sub-optimum dose of PSC833 on vincristine accumulation in MDR cells. Thus, we found major differences between the developmental pathways of non-galled leaves and galls. Contribution of radio-electrocardiography in the rehabilitation of CVA patients. The study included 12 patients affected by primary aldosteronism (PA) and 6 healthy control subjects (HCs), whose RBCs were compared with those of patients with PA.

iscover 75 mg side effects

Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancer. It may be particularly appropriate for large scale screening studies whose aim is to identify mutants with altered phenotypes or novel compounds with particular efficacy. The market forces in health care can not be left without control The present results do not distinguish whether any or all of these long-loop reflexes are segmental or supraspinal in origin. This article provides details on this special camp and how to find out more about similar camps around the U.S.

rezistencija na clopidogrel tablets

In addition chemicals such as diethylstilbestrol (DES) in humans and dichlorodiphenyltrichloroethane (DDT) in wildlife influence the reproductive system. Value of auto-fluorescence spectrum combined with tumor markers in diagnosis of lung cancer In addition, one adjacent vertebral body was measured in each patient as a control. Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder affecting school-age children. RPT-0001 and its capping for green synthesis of silver nanoparticles.

iscover 75 mg filmtabletten nebenwirkungen

Populations of 311 cannabis users and 197 amphetamine users from the Rosita-2 Project were studied. Further investigation of more specific predictors of HSR in the US middle south region is warranted, and patients being treated with cetuximab in this area should be observed particularly closely during their first infusion. The aim of this study was to evaluate the behaviour of soluble ICAM-1 (sICAM-1) in chronic hepatitis C (CH-C) patients with persistently normal aminotransferase in comparison with patients with CH-C and elevated aminotransferase, and its changes during alpha-interferon (IFN) therapy.

iscover 75 mg vademecum

Subjective health complaints of teachers from primary and secondary schools in Hong Kong. Determinants of medicine use in a Swedish primary health care practice population. It is a potentially repeatable procedure because of the lack of coagulation damage to the trabecular meshwork (TM) and also effect in patients with previously failed ALT. Bacterial infection (BI)-INDEX: an improved and simplified rapid flow cytometric bacterial infection marker.

iscover 75mg filmtabletten

Various studies also suggest that tPA plays important roles in the nervous system. NLN position statement on nursing roles - scope and preparation.

nebenwirkungen iscover 75 mg

All the members encode active TPP enzymes, possibly regulating the levels of trehalose-6-phosphate, an established signaling metabolite in plants. The recurrence of the hemolytic uremic syndrome (HUS) in a renal transplant patient during pregnancy and during treatment with cyclosporin is reported. Genetically constructed microbial biosensors for measuring organic pollutants are mostly applied in aqueous samples.

iscover 75 mg vademecum

However, the cellular implementation of this computation remains elusive. After damage detection, additional processes to enhance accessibility within chromatin may be needed to accommodate downstream repair factors or to allow DNA synthesis, resulting in interdependency between repair and accessibility mechanisms in chromatin. Rotifers (Brachionus plicatilis), commonly used at first feeding in commercial fish hatcheries, carry a large bacteria load.

iscover 75 mg side effects

Infection of Chang cells with hepatitis C virus using hepatic biopsy specimens from patients with chronic hepatitis (type C). Analysis, quantification, and evolutionary consequences of HIV-1 in vitro recombination. He had immediate pain and reduced circulation in his ring and little fingers.

iscover 75 mg preisvergleich

Right ventricular infarction: pathophysiology, diagnosis and treatment In this review, we present evidence that dopamine and dopamine receptors play an important role in regulating renal sodium excretion and that defective renal dopamine production and/or dopamine receptor function may contribute to the development of various forms of hypertension. A device that uses infrared reflectometry for monitoring the respiratory waveform of small rodents during MRI was developed. These recommendations have since been extended to dose response assessment. At times it varies within the same fetal membrane or from fetal membrane to fetal membrane considerably, where by the variation in membrane thickness also is of influence.

mhra drug safety update clopidogrel medication

Pulmonary embolism in stroke: prevention by early heparinization of venous thrombosis detected by iodine-125 fibrinogen leg scans. Modification of the arthroscopic Brostrom procedure with the use of bone tunnel may reduce the risk of certain complications. We begin with a historical survey and then compare attributes of the microjet and coated-wheel techniques, developed by Manfred Faubel and John Fenn, respectively, for studies of high- and low-vapor pressure liquids in vacuum. Several plastocyanin and cytochrome c6 site-directed mutant strains affecting both the acidic and hydrophobic regions of the two metalloproteins, which were previously characterized in vitro, have been constructed. These patients are a unique subset of patients with chronic kidney disease.

iscover 75mg side effects

Conventional logistic regression models and multilevel logistic regression models were fit to a cross-sectional cohort of patients hospitalized with a diagnosis of acute myocardial infarction. Autism spectrum disorders as a qualitatively distinct category from typical behavior in a large, clinically ascertained sample. Protozoan richness was strongly affected by top-down impacts of abundance of invertebrates. T(2)-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 Tesla.

iscover 75 mg beipackzettel

Loss of projection of the zygomatic arch may occur with injuries confined to the orbitozygomaticomaxillary region or in association with complex midfacial fractures. We report a case of a patient with intrathoracic extramedullary hematopoiesis presenting as a posterior mediastinal tumor, without associated myelofibrosis. In the present study we utilized ER-beta affinity purified polyclonal (N19:sc6820) and ER-alpha monoclonal (clone h-151) antibodies. However, Arabidopsis nectaries, along with those of related species, are quite operational and can be used to discern molecular mechanisms of nectary form and function. Newer clinical and radiographic features of seronegative spondyloarthropathies.

rezistencija na clopidogrel tablets

On the other hand, the similar rates on X and Y indicate that the number of DNA replications (higher for Y than for X) is also not the main factor. Comparison of three immunological methods for detecting staphylococcal enterotoxins from food. How the ICU follows orders: care delivery as a complex activity system. A study was undertaken to test the effect of 2 commercially available probiotics on the production efficiency of broiler chickens hatched from the same breeder flock at 3 different ages (28, 43, and 57 wk).

iscover 75mg filmtabletten

Comparison of Real-Time Fluorescent Indocyanine Green and (99m)Tc-Nanocolloid Radiotracer Navigation in Sentinel Lymph Node Biopsy of Penile Cancer. Luteal cells prepared from porcine ovaries collected from crossbred mature gilts on Days 10-14 of the estrous cycle were isolated and examined as follows: 1) Flow cytometric analysis was carried out to determine apoptosis in cultured luteal cells.

clopidogrel 75 mg r 196

This vector allows, on X-Gal (5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside) plates, a quick colorimetric blue-white discrimination of bacteria which have lost the plasmid, greatly facilitating clone identification during mutagenesis. However, only 1 of 17 renal biopsies of IgAN embedded in paraffin was positive for HCMV-DNA. Spectral and temporal responses of trunk extensor electromyography to an isometric endurance test.

clopidogrel side effects cough

The number of bone, lung, and kidney scans has decreased because of advances in other imaging modalities. Smaller varicosities were observed in the interior of these neurohemal and glandular organs, and a network of 5-HT fibers was occasionally found around the corpus cardiacum and corpus allatum.

aspirin and clopidogrel bilayer tablets with keyboards

Endothelin, a potent vasoconstrictor, is produced in and is active in the uteroplacental vasculature. Bilateral simultaneous femoral osteotomies for the late stages of osteoarthritis could be an alternative to bilateral total hip arthroplasties.

clopidogrel missed doses

Nucleotide sequence analysis identified an ORF encoding a protein of 351 amino acid residues. Dorsal closing wedge osteotomies are commonly done in order to elevate and shorten the metatarsals in the management of severe metatarsalgia with callus formation.

 Show Hide 
iscover 75 mg preisvergleich 2017-09-02

We recently reported the cloning of a new member of the serotonin 5-HT2 family, the 5-HT2B receptor. Selected topics from the XI International HIV Drug Resistance Workshop, Seville, and the XIV International AIDS Conference, Barcelona. The results showed that the method is good for predicting the fetal outcome and once again supported the hypothesis that metronidazole mode of action ppt spasm of arterioles and venules in the placenta leading to high peripheral resistance especially in the fetal side may play an important role in the pathogenesis of PIH.

iscover 75mg side effects 2011-04-02

The cytologic picture showed bland groups of uniformly sized cuboid cells with scant cytoplasm, round to ovoid nuclei, and inconspicuous nucleoli, while in the groups rosettelike structures could be moxilen 250 dosage calculator discerned. The specimen was plated onto blood agar, incubated at 37C, and examined for growth at 24 and 48 hours. Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.

iscover 75 mg side effects 2015-06-01

A pilot study was conducted to develop a monitoring instrument for the measurement of productivity in nutrition programs for the elderly. A syndrome of osteogenesis imperfecta, microcephaly, and cataracts. The use of interlocking detachable coils (IDC) which can be levofloxacin 250 mg tablets retracted or repositioned prior to full deployment is recommended. Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A.

pidovix clopidogrel 75 mg 2017-09-13

Directed electrodeposition of polymer films using spatially controllable electric field gradients. These findings of a concordant bicompartmental dopaminergic deficit in neurologic WD provide in vivo evidence for assigning WD to the group of secondary Parkinsonian syndromes. In this study, we have expressed the cDNA for sFlk-1 under the control of cytomegalovirus immediate-early promoter (CMV) from an E1/partial E3 deleted replication defective recombinant adenovirus, and Ad.sflk-1 expression was determined by Western blotting. stocrin 600 mg Future research should be directed at understanding the full constellation of needs encountered by parents during this time. Parasites have developed myriad strategies to reach and infect their specific hosts.

clopidogrel side effects cats 2015-05-06

The authors found five cases of PSL and divided them into two cases of cutaneous leiomyosarcomas and three cases ofsubcutaneous leiomyosarcomas. apo pantoprazole ingredients in tylenol These findings indicate that the selective loss of E-cadherin expression can generate dedifferentiation and invasiveness of human carcinoma cells, and they suggest further that E-cadherin acts as an invasion suppressor. The symptomatology displayed, along with the scrotal echograph, made us suspect the existence of testicular tumoration, which led us to carry out surgical exploration. Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells.

site of action of clopidogrel 75mg 2019-11-10

Treatment of UTI with aerococci is complicated by uncertainty about the effect dalfaz uno 10 mg cenapred of trimethoprim-sulphametoxazole and fluoroquinolones on aerococci. Multidetector-row computed tomography (MDCT) was used to examine the cause of PVD before reoperation. Here, a k-wave MATLAB toolbox was used to simulate various configurations of excitation pulse shape, width, transducer types, and target object sizes to see their effect on the photoacoustic/thermoacoustic signals.

nebenwirkungen iscover 75 mg 2012-07-18

Two alternative cumulative exposure indices are used--hours in excess of a threshold, and the sum of concentrations above a threshold. It is argued that these social capital adaptations spitomin tablets for sale have the effect of changing livelihood policies, institutions, and processes (PIPs), and clarify the impact of the distribution of power and powerlessness on food security issues. However, because of its practical difficulties, the spot urinary protein/creatinine (P/C) ratio has been utilized.

iscover 75 mg preisvergleich 2013-11-21

The relative deformations and stress distributions in six different designs of implant-supported prosthetic systems (six or four implants, with or without distal cantilevers, cross-arch or midline-divided bar into two free-standing bridges) were analysed by a three-dimensional finite element (FE) model of a human edentulous mandible. In B10 congenic strains, the TNF allele detected by microsatellite polymorphism segregated with the MHC, and in recombinant wellbutrin weight gain stories for feeders haplotypes (NOD, NZW), it segregated with H-2D. Chronic pain prevalence was higher among males reporting job dissatisfaction compared with those reporting job satisfaction. This standardized assay was used to analyze human verruca plantaris tissue for genome type and to evaluate the effect of a commonly used treatment protocol.

clopidogrel mode of action ppta 2011-10-25

The Kansas strain of bovine parainfluenza virus type 3 (BPIV3) is 100- to 1,000-fold restricted in replication in the respiratory tracts of nonhuman primates compared to human PIV3 (HPIV3), an important pathogen of infants and young children. The development of homogenously nano-patterned chemically modified surfaces that can be used to initiate a cellular response, particularly stem cell differentiation, in a highly controlled manner without the need for exogenous biological factors has never been reported, due to that fact that precisely defined and reproducible systems have not been available that can be used to study cell/material interactions and unlock the potential of a material driven cell response. Stability and catalytic activity of alpha-amylase from barley malt at different prediksi recreativo huelva vs levantes pressure-temperature conditions.