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Dutasterida (Dutasteride)
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Dutasteride

Dutasterida, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Dutasterida is generally safe and well tolerated. Dutasterida has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Dutasterida may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

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Knowledge of the state-of-the-art CT imaging techniques that are used for evaluating congenital heart disease is helpful not only for planning and performing CT examinations, but also for interpreting and presenting the CT image findings that consequently guide the proper medical and surgical management. After monthly evaluation for 4 months using in vivo confocal microscopy, 2 corneas were processed for histologic analysis and were sectioned serially.

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Autophagy has also been suggested as a possible mechanism for non-apoptotic death despite evidence from many species that autophagy represents a survival strategy in times of stress. To demonstrate the functional relevance of EREG-producing tumor-associated fibroblasts, we developed a novel system for adoptive transfer of these cells via mini-endoscopic local injection. 5 g/L-20 g/L ephedrine stimulated CBF, then 10 g/L-20 g/L ephedrine inhibited CBF. Solid-phase supported synthesis: a possibility for rapid scale-up of chemical reactions. Potassium contracture of smooth muscle in the presence of dextran.

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Based on these findings and their convergence with studies of completed suicides, prevention of suicidal behaviour in primary care should probably focus more on high-risk subgroups of depressed patients, including those with moderate to severe major depressive disorder, personality disorder or a history of psychiatric care. Our objectives were to avoid severe 5-FU toxicities in patients with greatly impaired 5-FU and 5-FDHU pharmacokinetics after the administration of a reduced test dose of 5-FU and to investigate possible 5-FU or 5-FDHU pharmacokinetic parameters of the test dose related to the most common drug toxicities that affect patients after the first cycle of 5-FU chemotherapy.

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Fatty acid synthase gene regulation in primary hypothalamic neurons. Gene-rich and gene-poor chromosomal regions have different locations in the interphase nuclei of cold-blooded vertebrates. Evaluation of the relationship between bruxism and premature occlusal contacts. It has molecular mass of 61-65 kDa in the species of virilis group, 33-36 kDa in species of obscura group, and 34-56 kDa in species of melanogaster group. Severity of the disease is categorized into three levels: mild, moderately severe and severe, depending upon organ failure and local/systemic complications.

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If equity is a goal in public health care, we should know more about its actual use. Observation of large intraventricular tumours with inhomogeneity on T2-weighted images and flow void is suggestive of CPTs. We investigated the hypothesis that decline in performance with age results in increased cognitive control, as indexed by greater activity within the ACC and lateral PFC. MRSA was likely spread predominantly during practice play, with skin breaks facilitating infection. The percentage atrazine degraded in the freshly treated soils was much higher than that in the aged soils.

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The Data base documents data used by the ET nurse as she formulates her plan of care for the patient with an ostomy. They also completed the Memorial University Scale of Happiness (MUNSH) prior to entry and after three months.

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Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs. A microarchitectural model of regional variations in hypodermal mobility in porcine and human skin. Many experimental studies have been performed to understand the pathological and biomechanical factors associated with diffuse brain injuries. The clinical course of the disease and changes of tolerance of physical load were studied in two groups of patients. An additional degree of selectivity can be achieved through the incorporation of shape complementarity on the nanoparticle surface.

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Differences in attentional set between athletes and nonathletes. Purification of elongating RNA polymerase II and other factors from yeast chromatin.

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The purpose of this study was to investigate whether the effect of transdermal estrogen therapy in postmenopausal women differs from that of oral therapy with regard to resistance to activated protein C (APC), an important risk factor for venous thrombosis, and levels of related proteins, such as protein S, protein C, and prothrombin. Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Most positron emitters are produced by cyclotrons and have very short half-lives.

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Apo A-I, a known acceptor of cholesterol transported by ABCA1, elevated cholesterol efflux on the basal side, whereas the others raised cholesterol efflux on the apical side. This device offers an effective tool with precise control over the vibratory stimulus, delivering higher forces than some other types of devices (e.g., piezoelectric actuators).

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When compared with their wild-type parents, melanogenic mutants (i) exhibited a lower fitness in growth conditions found in human tissues, such as hyperosmolarity and presence of aminoglycoside antibiotics, (ii) narrowed their metabolic spectrum with a growth disadvantage with particular carbon sources, including aromatic amino acids and acyclic terpenes, suggesting a reduction of metabolic flexibility. In the present study, quantitative in situ hybridization was used to evaluate changes in these mRNA levels during acute (2 and 7 days) and chronic (30, 90, and 180 days) streptozotocin-induced diabetes mellitus (STZ-DM).

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This study demonstrates that lignan phytoestrogens may have a protective effect against incontinence in postmenopausal women. Changes in the pollen seasons of the early flowering trees Alnus spp.

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The clinical phenotype of asthma is notoriously heterogeneous and is affected by genetic and environmental exposures in addition to interactions between airway structural cells, including epithelial cells, and the immune system, as well as contributions from cells other than T(H)2 cells. In milk-hypersensitive subjects, milk challenge increased significantly the expression of CR1, FcgammaRI and FcalphaR in neutrophils and CR1, CR3 and FcalphaR in monocytes.

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Clinical features and risk factors associated with interstitial lung disease in patients with classic dermatomyositis or clinical amyopathic dermatomyositis However, scanning electron microscopy and beta-tubulin staining revealed a significant change in terms of the cell morphology and cytoskeleton caused by the bare gold particles. Production of cell cultures from mesenchymal stem cells of the human bone marrow and their use in medicine The post-operative natural change observed by radiography and scintigraphy at the site of the roof of acetabulum was statistically significant (p less than 0.01) by the chi-square test. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration.

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The stages of change in smoking cessation in a representative sample of Korean adult smokers. LOH on 9p and 17p are highly frequent events in BE, even in the absence of dysplasia and adenocarcinoma. In 3 patients, immunoscintigraphy influenced the management of the patient. Multiorgan Langerhans cell histiocytosis (LCH) presenting in the neonatal period is associated with a poor prognosis.

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Results of skin tests with venom extracts from bees and wasps in patients with insect allergy Systematic review on the incidence and risk factors for parasitic myoma after laparoscopic morcellation. This effect appears to involve, at least in part, androgen receptor occupancy in the amygdala. Gradual Growth of Spontaneous Dissecting Aneurysm of the Extracranial Internal Carotid Artery After Aneurysmal Subarachnoid Hemorrhage. Successful percutaneous pulse spray thrombolysis of extensive acute portocaval hemitransposition thrombosis.

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A case of 4-year-old girl is presented, brought threaded-alive on wooden picket due to head-on fall from roof with wooden picket entering through left subcostal region and exiting from right buttock. To investigate the fluorescent characteristics of different thyroid tissues. Possibilities of diagnostic standardization in the differential diagnosis of comatose conditions on the basis of the working methods of a grade IIb laboratory Biomechanical measures assessed in simulated bed falls were below known head injury criteria and lower extremity injury thresholds.

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Collagen type IX, 3-sulphoglucuronic acid (HNK-1 epitope), biglycan and heparan sulphate proteoglycans were detected in Western and dot blots by using specific monoclonal antibodies (MAbs). Prooxidant-induced c-Src/nuclear factor kappa B-coupled signalling in sensory ganglia mediates cutaneous hyperalgesia. Because laparoscopic liver resection (LLR) has a steep learning curve, analyzing experience is important for trainees. Clinical and urodynamic parameters associated with history of urinary tract infections in women.

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