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Terbinafine
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Terbinafine

Terbinafine has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the nails.

Other names for this medication:
Terbinafine, Lamisil,

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We describe two cases of facial nerve injury after lateral external dislocation of the mandibular ramus, an event not found in the reviewed literature. Dihydrotestosterone levels in prostatic tissue and serum were analyzed using liquid chromatography/electrospray ionization-mass spectrometry after polar derivatization.

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Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver. FBI-1 mRNA was expressed in human adipose tissue with the highest levels found in samples from morbidly obese subjects.

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To test this hypothesis, we looked for the expression of the lymphatic endothelial cell-specific markers LYVE-1, Prox-1, podoplanin and D2-40 in beta4 integrin-negative proliferating and beta4 integrin-positive involuting infantile hemangiomas. Thrombotic microangiopathy associated with combined sirolimus and tacrolimus immunosuppression after intestinal transplantation.

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Only in few cases the surgical treatment of a coronary artery disease in combination with left ventricular outflow tract obstruction and heavily calcified ascending aorta has been described. Above the age of 60 years there was no important or significant relation between IHD mortality and treated DBP. Oral theophylline has, for many years, been used as a bronchodilator in patients with COPD. The direction of the infrapatellar branch of the saphenous nerve is location-dependent. However, most of these fail to meet the requirements of a good therapeutic effect, time and cost efficiency, non-invasiveness and applicability without the need for additional devices or drugs.

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Electric charge quantization from gauge invariance of a Lagrangian: A catalogue of baryon-number-violating scalar interactions. To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis. The validity of the DSM-III posttraumatic stress disorder classification as applied to children. Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis.

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In addition to behavioural abnormalities, we identified anatomical alterations in the olfactory bulb, piriform cortex, hippocampus and cerebellum. Early-onset colorectal cancer (CRC), defined here as age of onset less than 40 years, develops frequently in genetically predisposed individuals.

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These data indicate that both PKC and the influx of extracellular calcium play a role in the induction of zif268 mRNA following activation of the m1 mAChR. The authors discuss here the neurobiological basis of panic disorders and cochleovestibular dysfunction. Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. Viewing gave some a greater sense of attachment to the fetus, but for a few, this attachment also gave a greater sense of vulnerability with regard to the outcome of the pregnancy.

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Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. Dechlorination of PCBs in water under UV irradiation and the relationship between the electric charge distribution on the carbon atom and the site of dechlorination occurrence. Effect of low versus high intravenous amino acid intake on very low birth weight infants in the early neonatal period. We discuss current preclinical and clinical data, as well as data from clinical trials of targeted therapies that are either ongoing or in development for MB.

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The BDI and TDI thus appear to be useful measures in ALS and may have both clinical and research applications. Long-wavelength absorbing antenna pigments and heterogeneous absorption bands concentrate excitons and increase absorption cross section. Agreement among neurologists on the clinical diagnosis of dystonia at different body sites. Tumours are now considered as complex tissues including endothelial cells of the tumour vasculature, which can decrease radiotherapy efficacy. Treatment suggestions are summarized in 4 groups, each characterizing a specific therapeutic approach: 1) psychopharmacological proposals (that is, psychotropic drugs), 2) therapeutic counselling (from a psychologist or psychiatrist or psychotherapy), 3) alternative suggestions (such as homeopathy), and 4) social advice (for example, from a social worker).

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Consequently, we became interested in using RNAi to determine the function of aberrantly expressed ErbB3 in the KAS-6/1 human myeloma cell line. This article reviews pertinent pain management principles, including pain vocabulary, barriers to pain management, and general pain assessment and treatment measures. Furthermore, incubation of promastigotes at 37 degrees C with Matrigel matrix, a soluble basement membrane extract of Engelbreth-Holm-Swarm tumor cells, stimulated the release of internal MSP but not of surface-located MSP. We studied patients in an integrated health care delivery system with newly diagnosed coronary heart disease. This special issue of Trends in Parasitology comprises a collection of timely reviews arising from the 2nd Molecular Approaches to Malaria meeting held 1-5 February 2004 in Lorne, Australia, four years after the successful inaugural meeting.

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A comparative rewarming trial of gastric versus peritoneal lavage in a hypothermic model. Modifications in implant design and techniques enable the surgeon to apply and combine the essential components of the basic principles for the treatment of mechanically impaired bone. It is not clear that such guidelines actually codify standards of care.

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We tested this relationship by examining spatial language in children with Williams syndrome (WS), a rare genetic disorder that gives rise to severe nonlinguistic spatial de deficits together with relatively spared language. Also, the number of strongyles found in the gut contents of group TF foals were significantly reduced in the dorsal colon, but numbers of worms in the ventral colon and in the caecum were similar to those of the controls. Effect of alternaria pathotoxin(s) on expression of p53-like apoptotic protein in calli and leaves of Brassica campestris. An inactive enantiomer of phorbol ester, 4alpha-PDD, had no effect on the ET-1 production in these cells of both rat strains.

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Detection and identification of human Plasmodium species with real-time quantitative nucleic acid sequence-based amplification. These mononitrates relaxed vascular tissue in a concentration-dependent manner. While previous empirical research on income inequality and physical health is equivocal, evidence for income inequality effects on mental health seems to be strong. A sexual dimorphism in thymidine kinase activity occurred in control rats between 6 and 15 days of age, i.e., enzyme activity was significantly higher in the cerebellum of the female rats. The weight of the genitourinary tract, seminal vesicles and the prostate as well as animal survival were monitored.

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Basement membrane components are synthesized at high levels during development. Scanning-tunneling-microscope study of antiphase domain boundaries, dislocations, and local mass transport on Au(110) surfaces. In the first part of this report, the role of morphological techniques for studying the biology and pathology of peroxisomes is reviewed, and the techniques established in our laboratories for the localization of peroxisomal proteins and corresponding mRNAs in fetal and newborn mice are presented and discussed in the context of the international literature.

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An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice. Reduction in visceral slide is a good sign of underlying postoperative viscero-parietal adhesions. There is considerable scatter in phonation pressure and phonation onset time across speakers and utterances. Autoantibody formation to citrullinated (pro)filaggrin has proven to be a highly specific serological marker for rheumatoid arthritis (RA). A retrospective analysis of 87 patients undergone endoscopic sinus surgery was made.

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Outcome of failure in clearing the oesophageal margin in total gastrectomy for adenocarcinoma. Metabolic risk factors and the effect of metaphylaxis in pediatric stone disease with hypocitraturia. The treatment of anaemia in the myelodysplastic syndromes with recombinant human erythropoietin. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. Effects of aquatic therapy on joint flexibility and functional ability in subjects with rheumatic disease.

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Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer. The hepatitis B markers also were tested in 44 sera positive for yellow fever antibodies. The apoptosis induced by yogurt as a mechanism involved in the inhibition of an experimental intestinal tumor induced by 1,2 dimethylhydrazine (DMH) in BALB/c mice, has been studied. H1- and H2-histamine receptors linked to adenylate cyclase in cell-free preparations of guinea pig cerebral cortex. This type of large-scale computational scanning could be coupled with proteomic and metabolomic studies of this parasite leading to novel therapeutic intervention and disease control strategies.

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Chronic liver disease in Ethiopia: a clinical study with emphasis on identifying common causes. Lowest-Landau-level constraint, Goldstone mode, and Josephson effect in a double-layer quantum Hall system. Despite the considerable and growing body of research about the clinical effectiveness of long-term psychoanalytic treatment, relatively little attention has been paid to economic evaluations, particularly with reference to the broader range of societal effects.

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Muscarinic receptor function and acetylcholinesterase activity after chronic administration of tacrine to mice at therapeutic drug concentrations. These data emphasize the important role of these structures as primary targets for circulating AMY. The extent of association of human papilloma virus (HPV) in human conjunctival neoplasias has been debated in studies originating from different parts of the world, but no substantial evidence has been generated on Indian subjects.

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PBMCs are potentiated to react with exogenous antigens upon treatment with LLME. Tenascin staining was intense in the stroma of hypertrophic synovial membranes, particularly on the surface of severely hypertrophic synovial membranes with inflammation, proliferation, irregular lining structures and new capillary growth.

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Images of the environment, taken by a camera are pre-processed by an external visual encoder. The samples were examined by indirect immunofluorescence and immunoelectron microscopy using anti-human type IV collagen antibodies produced by immunizing rabbits with type IV collagen extracted from human placenta. In 17 patients, surgical treatment was thought to be either risky or difficult due to the presence of a serious medical condition or because of the peripheral location of the lesion.

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Flexible fiberoptic bronchoscopy was initially performed on each patient to confirm the presence of a foreign body and identify the anatomic position with the airway. Our results show that, depending on the probe intensity, detection of THz waves in air can be categorized as incoherent, hybrid, and coherent detection. Ninety-two per cent had at least three parathyroid glands preserved. Unusual behavior of CMC for binary mixtures of alkyltrimethylammonium bromides: dependence on chain length difference. Besides its known role as a marker of left ventricular dysfunction, experimental evidence suggests a role of NT-proAtrial Natriuretic Peptide (NT-proANP) also in modulating pulmonary circulation.

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Optical manipulation of aerosol droplets using a holographic dual and single beam trap. How many ligations of bilateral segmental arteries cause ischemic spinal cord dysfunction? This could be the result of a higher intake of U from liquids, as assessed by the determination of U concentration in drinking waters. Three patients have since died of metastatic disease, one has died of unrelated causes but with no residual disease and the remainder were alive and well at follow-up intervals ranging from 11 to 60 months. The main receptor for NO is guanylyl cyclase leading to formation of smooth muscle cyclic guanosinmonophosphate and relaxation.

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Bacterial disintegration reta and release of the components are determined by the intensity of the inflammatory response in the subarachnoid space. IVIG may be a useful adjunct therapy for infective endocarditis and sepsis. Human sperm survival assay as a bioassay for the assisted reproductive technologies laboratory. Analysis of reproductive isolation between sibling species anopheles Albitarsis sensu stricto and Anopheles deaneorum, two malaria vectors belonging to the Albitarsis complex (Diptera: Culicidae).

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Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Taken together, the results suggest that mitochondrial oxidative stress induces the synthesis of MT, which may contribute to regulation of mitochondrial ROS production.

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These animals express the full length core protein in cytoplasm of their hepatocytes at levels comparable to those detected in naturally infected patients, without histological or biochemical evidence of liver disease or hepatocellular carcinoma. Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation.

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Use of a derivative of Escherichia coli BL21(DE3) for efficient production of three different recombinant proteins. The clinical presentation and ocular complications were evaluated. In some wealthy countries, cystic echinococcosis caused by Echinococcus granulosus has been successfully controlled or indeed eradicated. Ascidian tyrosinase gene: its unique structure and expression in the developing brain. This review specifically addresses the pioneering approaches to improve induced pluripotent stem cell based models of nonischaemic cardiomyopathy.

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Hiccups and dysphonic metallic voice: a unique presentation of Twiddler syndrome. The goal of this study was to identify the best extracellular matrix protein for enhancing osteogenesis by hMSCs (human mesenchymal stem cells) and to investigate the underlying mechanism. All of the patients had thyroid gland uptake of the Tc-99m MIBI underwent laboratory evaluation of thyroid function, ultrasonographic imaging, and hystopathological examination. Low-grade astrocytoma: surgical outcomes in eloquent versus non-eloquent brain areas. Effects of transforming growth factor beta 1 on the expression of integrin beta 3 and the activity of focal adhesion kinase on human vascular endothelial cell

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