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Cycloblastin (Cyclophosphamide)
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Cyclophosphamide

Cycloblastin is used to treat a variety of different cancers. It is also occasionally used to treat severe symptoms of some connective tissue diseases (such as rheumatoid arthritis) although these are not cancers. In cancer, certain cells in the body grow and multiply too fast. Chemotherapy medicines like Cycloblastin work by preventing cells from multiplying. This reduces the number of cancer cells made. Cycloblastin is often given alongside other medicines to help treat cancer.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Only if the psychosocial aspects are taken into account can patients with NVD be offered a therapy that treats the causes of the voice disorder. In review of the literature there is one neonatal report of NF associated with necrotizing enterocolitis. Differences in gene expression are detectable using microarrays, but microarrays have traditionally been applied to pancreatic cancer tissue obtained from surgical resection.

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The nature of the diradical intermediates as well as the transition states was established computationally. The effects were most apparent in the muscles responsible for the pinch force, the forearm muscles. The anticoagulant and antiplatelet aggregation potential of a series of six synthetic 1,2,3-triazole derivatives were investigated through in vitro models. The aim of this study was to investigate the involvement of the MT1-MMP/MMP-2 cascade in induced sputum (IS) and bronchoalveolar lavage fluid (BALF) from bronchial asthma (BA) and bronchiectasis (BE) patients and healthy controls.

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Bursitis, adventitious bursae, and areas of localized soft-tissue inflammation are different aspects of the same disorder resulting from a mechanical conflict between the stump and the prosthesis socket. On the basis of these data, we performed an exploratory clinical study, assessing the efficacy of itraconazole with cytotoxic chemotherapy in the treatment of patients with advanced lung cancer. If not, data are presented from review articles that summarize the foreign study.

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These are described, together with the principles of cryopreservation of stem cells. The aim of this study was to investigate the effects of ALE on bile flow and the formation of bile compounds in anaesthetised Wistar rats after acute and repeated (twice a day for 7 consecutive days) oral administration. The anatomic landmarks of the depth of invasion for pedunculated lesions (Haggitt level) and the Sm system for the sessile lesions give excellent objective information in the management of malignant colorectal polyps. The data consisted of test day records of 9516 first lactation dairy cows and the records of 6358 of these cows that went on to produce a second lactation.

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Antibodies raised against expressed sequences recognized a glucocorticoid-inducible 130-140-kDa protein on immunoblots of DDT1 cell lysates. To determine the polymorphism at position 247 of the beta(2)-glycoprotein I (beta(2)GPI) gene in Mexican patients with antiphospholipid syndrome (APS) and to compare these data in patients with or without antibodies to beta(2)GPI and with the clinical manifestations of APS. Differences between tonsil surface and core bacterial flora may have implications in the etiopathogenesis and treatment of chronic tonsillitis. Heat shock response is an adoptive response to proteotoxic stress, and a major heat shock transcription factor 1 (HSF1) has been believed to protect cells from cell death by inducing heat shock proteins (Hsps) that assist protein folding and prevent protein denaturation. Anesthetized Long Evans rats show similar protein expression and long-term potentiation as Fischer 344 rats but reduced short-term potentiation in motor cortex.

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The contents of panaxadiol and panaxatriol in Shihu Yeguang Pills manufactured by pharmaceutical works in Beijing, Jinan, Guangzhou and other places were determined by TLC-densitometry. Fat mtDNA and plasma triglycerides, cholesterol, glucose, insulin, leptin and adiponectin levels were unchanged. Long-term Zn deficiency affects the neuronal, immune, and hematopoietic systems, which contribute to systemic and/or local circulation.

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Monitoring Trastuzumab Resistance and Cardiotoxicity: A Tale of Personalized Medicine. Eleven different sequences were detected and two selected as reference DNA in a heteroduplex mobility assay (HMA). The EuroQol valuation technology was used to administer the protocol as well as to collect the data. Nonlinear conductance fluctuations in quantum wires: Appearance of two different energy scales. We investigated the efficacy of a biocide Umonium38 on multidrug-resistant strains by comparison with a chloride derivative (Decs).

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The biodistribution of bevacizumab was investigated using peritoneal metastatic models together with subcutaneous xenografts, and (125)I-radiolabelled bevacizumab was administrated to these models subcutaneously (s.c.) or intraperitoneally (i.p.), respectively. In this study, we propose a slice-wise augmented active shape model (AASM) approach to robustly segment both the outer and inner surfaces of the abdominal wall. Elongation/compaction of giant DNA caused by depletion interaction with a flexible polymer. Direct-to-consumer television advertising: time to turn off the tube? There were a limited number of general minor complications in this series that did not include cases of regrowth or malignant transformation.

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Topical vapocoolant quickly and effectively reduces vaccine-associated pain: results of a randomized, single-blinded, placebo-controlled study. Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma. General guidelines for the assessment of internal dose from monitoring data: progress of the IDEAS project.

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The refeeding syndrome is a potentially lethal complication of refeeding in patients who are severely malnourished from whatever cause. The study of hexagonal boron nitride (hBN) in microfluidic and nanofluidic applications at the atomic level requires accurate force field parameters to describe the water-hBN interaction. Dissociation of this module is possible, although less probable than changes in the independently evolving abdominal region. Different pharmacomodulations have been explored and the lipophilicity of these compounds was assessed. In optical lattices where each site is occupied in its lowest energy state by a superposition of zero, one, and two atoms, one can in a controllable manner convert the atomic pair into a molecule while retaining the vacuum and one-atom amplitudes.

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The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat.

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Aluminum and strontium ions were also present in dentine except subjacent to Ketac Molar restorations. It involves a series of automatic algorithms including image segmentation, boundary smoothing, skeletonization and branch pruning, and takes into account the cell shape changes between successive frames to detect protrusion and retraction activities.

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thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates. The patients who received a high linoleic acid diet showed a lower cardiovascular death rate than the low linoleic acid group.

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Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation. Good agreement is achieved between the results obtained by the microfluidic chip device and the results from a commercial flow cytometer. The possibilities are entered to procede in this case successfully in operation.

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Caution to use bronchoscopic CO2 cryotherapy for foreign body removal in children. Control animals were either nonvaccinated or injected with aluminium hydroxide adjuvanted vaccine. Paclitaxel has been shown to activate Raf-1 and cause phosphorylation of Bcl-2, which has been correlated with paclitaxel-induced apoptosis of cancer cells. High capacity and exceptional cycling stability of ternary metal sulfide nanorods as Li ion battery anodes.

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Trace anesthetic vapors in hospital operating-room environments. Investigation of these patients adds further evidence to this condition being a separate pathological state from gastro-oesophageal reflux and eosinophilic enteritis. Latency of TFR in spinal rats did not differ from controls 1 day after transection, but decreased steadily thereafter.

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Ointments, creams, antifungals, and antibiotics all have their place in treating various skin diseases. Due to the neurohormonal activation there is an increase in the activity in the renin angiotensin system, in the adrenergic nervous system, and in the cytokine system. The contemporary treatment of the child infected with human immunodeficiency virus (HIV) unavoidably requires combination therapy with antiretroviral agents and may include additional drugs for the prevention and treatment of opportunistic infections or other disease states. Development of a severe combined immunodeficiency (SCID) mouse model consisting of highly disseminated human B-cell leukemia/lymphoma, cure of the tumors by systemic administration of immunotoxin, and development/application of a clonotype-specific polymerase chain reaction-based assay.

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During stress, oxygen and nutrient deprivation, or microbial infection, autophagy prolongs cardiomyocyte survival. The Lm-ActA-E7 vaccine was administered intraperitoneally to the mice 5 days after tumors were established. Some methods for achieving this are discussed and possible epidemiologic approaches to the evaluation of interventions against tropical diseases are outlined. Cytokines play a critical role in the control of the innate and adaptive immune responses. We determined the predictors of prostate specific antigen (PSA) doubling time in patients with relapse after radical prostatectomy as well as whether PSA doubling time is shorter in those treated versus not treated with neoadjuvant androgen deprivation therapy.

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Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. Our present study shows that the cone photoreceptor density is significantly reduced in HIV retinae compared with age-matched controls. A lethal toxin similar to Bacillus cererus lethal toxin was detected in the culture supernatants of Escherichia coli isolated from chickens with swollen head syndrome. This study was designed to compare the urodynamic parameters in women with bladder outlet obstruction (BOO), stress urinary incontinence (SUI) and asymptomatic volunteers. In vivo, however, the infarctions could not be visualized either before or after injection of dextran-(Gd-DTPA)15 or Gd-DTPA.

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uPAR(-/-) mice demonstrated a decreased LPS-induced neutrophil migration into peritoneal lavage fluid, whereas the chemokine and cytokine response was unaltered. Multiplex mutagenically separated PCR: diagnosis of beta-thalassemia and hemoglobin variants. The clinical, neuropsychological and computed tomography data were compared in elderly and senile patients with trembling and akinetico-rigid forms of parkinsonism. Clinical phenotypic expression of SSADH deficiency is highly heterogeneous, and some infants may develop refractory secondary generalized seizures. Lumbar spinal canal morphometry from computed tomography scans: reproducibility, results and clinical implications.

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Our study suggests that PET/CT imaging can be utilized to survey free-flap patients at acceptable levels of sensitivity/specificity. MRI in the diagnosis of so-called pituitary apoplexy: seven cases. Contrast constancy in natural scenes in shadow or direct light: A proposed role for contrast-normalisation (non-specific suppression) in visual cortex.

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57th annual meeting of the Japanese Association for Thoracic Surgery. We review the clinical features of the condition, and then discuss the steps in the anaesthetic process, outlining the anaesthetic implications of myotonic dystrophy at each stage. Inhibition of sporulation in the water mold Blastocladiella emersonii by antipain.

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Liver regeneration stimulated by HGF treatment may be closely involved with STAT3 activation in a different manner induced by IL-6 treatment. Using the TCI, temperament and character features of 28 bulimic patients and their parents (23 fathers and 28 mothers) were analyzed and then compared with a control group of 29 women and their 27 fathers and 29 mothers. Because the probe is 10 mm in diameter, it is currently only useful for skin and oral applications.

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Testes were examined with respect to diameters of seminiferous tubules (DST), ratios of malonyl dialdehyde and Johnsen biopsy scores (JBS), and PCD ratios. coli proteins important for DNA replication, the chi subunit of DNA polymerase III holoenzyme and the PriA helicase. Men seem to have a limited, but significant bone loss in subclinical hyperthyroidism.

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Venous diseases are highly prevalent and chronic wounds cause high morbidity and costs. In addition, these mice have phenotypes associated with cilia dysfunction, including retinopathy, renal cysts, male infertility, and a deficit in olfaction. In the healthy perimenopausal women study, we also found that MBP increased BMD, primarily by inhibiting bone resorption, while maintaining bone formation.

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Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method. Percentages of annual change were calculated with Joinpoint regression and data were stratified by sex and year of education.

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On the basis of a systematic review of the literature, this paper provides the first evidence-based maps of the distribution of the major vector-borne parasitic infections of dogs and cats in Europe. These findings suggest that cranberry supplementation is sufficient to promote longevity when implemented during any life stage, likely through reducing oxidative damage. The combined technique of corticosteroid injection and thumb spica casting was better than injection alone in the treatment of de Quervain tenosynovitis in terms of treatment success and functional outcomes.

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Endometrial cancer is the most common gynecologic malignancy seen in the United States. Thus, the present study suggests that very limited fusogenicity in virulent CDV infection, which favours persistence by limiting cell destruction involves complex interactions between all viral structural proteins. The relative impact of AS seems to diminish with increasing age.

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Local blood flux in skin and muscle during voluntary hyperventilation in healthy controls and patients with hyperventilation syndrome. With these limitations in mind, MAP recordings are a valuable addition to clinical electrophysiological studies. Distribution and estimation of anaerobic zoosporic fungi along the digestive tracts of sheep.

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For example, a new and improved virtual design of barb geometry is proposed and validated. Two cases of surgically treated brain stem cavernous angiomas are presented. The recombinant chimeric protein could be detected on blots probed with avidin-horseradish peroxidase and purified on immobilized monomeric avidin resins. PCR is the preferred detection method, and fresh or frozen specimens are the ideal source of tissue for evaluation. Clamps and snares are not advised and cautery of the orbital tissue is avoided.

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Recent progress of molecular genetical approach to human hereditary neurodevelopmental diseases is briefly reviewed, since it greatly contributes to our understanding on the pathogenesis of neuronal migration disorders. Here, we report that the Hsp90 cochaperone FKBP51 is upregulated in LAPC-4 AI tumors grown in castrated mice and describe a molecular mechanism by which FKBP51 regulates AR activity. In this paper we demonstrate the link between cardiac innervation and HRV in several species of teleosts because HRV is greatly decreased after vagotomy or atropinization. Evidence-informed education in the health care science professions.

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A recent study by Hung and colleagues (Am J Respir Crit Care Med 188(7):820-830, 2013) used genetic fate mapping of FoxD1 embryonic progenitor cells to show a major and direct contribution of mesenchymal cells to fibrogenesis in the lung. Given the potential predictive value of R702W, G980R, and 1007fs, a robust genotyping method for these variants would be of considerable value both in diagnostic and research settings. Stress-activated protein kinase (SAPK, also known as c-Jun N-terminal kinase, JNK) is activated by such stress stimuli. At the time of ICU discharge to the ward three factors are predictive of hospital outcome: timing of ICU discharge, limited medical treatment orders and initial illness severity.

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Atrazine exposure causes mitochondrial toxicity in liver and muscle cell lines. 5FU-treated TruMBD4 cells demonstrated diminished growth characteristics compared to controls, independently of hMLH1 status. Characterization and source of oil contamination on the beaches and seabird corpses, Sable Island, Nova Scotia, 1996-2005. Periventricular leukomalacia consists of diffuse injury of deep cerebral white matter, with or without focal necrosis. This is the first amcal fexo 180 dosage index attempt to account for subcellular distribution associated with Cd in P.

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For IN sounds, children learned homonyms more rapidly than novel words. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. HIV clendix dosage of tylenol testing in US tuberculosis care settings: a survey of current practice and perceived barriers.